Statsenko M E, Derevyanchenko M V
Volgograd State Medical University, 1, Pavshikh Bortsov Sq., Volgograd 400031, Russia.
Kardiologiia. 2015 Mar;55(3):17-20.
To evaluate the impact of a 12-week combined antihypertensive therapy with enalapril + indapamide on endothelial dysfunction in patients with arterial hypertension (AH) and diabetes mellitus (DM) type 2.
30 patients with AH stage II-III and DM type 2 age from 40 to 65 years were included into research. The combined antihypertensive therapy with enalapril 28,6+/-1,9 + indapamide 2,5+/-0 mg/day was assigned for 12 weeks. We studied endothelial function by determining the concentration of NO metabolites and endothelin-1 in serum and urine, the results of occlusion test.
After 12-week therapy, 100% of the patients achieved BP goals. There was no impairment of carbohydrate metabolism. Endothelial function was improved in hypertensive patients with T2DM: there were increases in both serum and urinary NO production (by 381 and 48,2%, respectively) and decreases in urinary endothelin-1 secretion (by 56,3%). The number of patients with normal microcirculation increased from 13.3 to 53.3% (p<0.001) by reducing the number of patients with abnormal (hyperemic and stagnant-stasic) types of microcirculation.
Twelve-week treatment with the combined antihypertensive medication The combined antihypertensive therapy with enalapril + indapamide is highly effective and safe for recovering endothelial function in hypertensive patients with T2DM.
评估依那普利+吲达帕胺联合进行12周降压治疗对动脉高血压（AH）合并2型糖尿病（DM）患者内皮功能障碍的影响。
纳入30例年龄在40至65岁之间的II-III期AH合并2型DM患者进行研究。给予依那普利28.6±1.9+吲达帕胺2.5±0毫克/天的联合降压治疗，为期12周。我们通过测定血清和尿液中一氧化氮代谢物和内皮素-1的浓度以及闭塞试验结果来研究内皮功能。
经过12周治疗后，100%的患者达到血压目标。碳水化合物代谢未受损害。T2DM高血压患者的内皮功能得到改善：血清和尿液中一氧化氮生成均增加（分别增加381%和48.2%），尿液内皮素-1分泌减少（减少56.3%）。通过减少微循环异常（充血性和停滞性-淤滞性）类型的患者数量，微循环正常的患者数量从13.3%增加到53.3%（p<0.001）。
依那普利+吲达帕胺联合降压药物进行12周治疗对T2DM高血压患者恢复内皮功能高效且安全。
