Department of Cardiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, China.
Department of Cardiology, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, 530023, China.
Sci Rep. 2017 Mar 15;7:44376. doi: 10.1038/srep44376.
Various stem cells have been explored for the purpose of cardiac repair. However, any individual stem cell population has not been considered as the ideal source. Recently, trophoblast stem cells (TSCs), a newly described stem cell type, have demonstrated extensive plasticity. The present study evaluated the therapeutic effect of TSCs transplantation for heart regeneration in a mouse model of myocardial infarction (MI) and made a direct comparison with the most commonly used mesenchymal stem cells (MSCs). Transplantation of TSCs and MSCs led to a remarkably improved cardiac function in contrast with the PBS control, but only the TSCs exhibited the potential of differentiation into cardiomyocytes in vivo. In addition, a significantly high proliferation level of both transplanted stem cells and resident cardiomyocytes was observed in the TSCs group. These findings primary revealed the therapeutic potential of TSCs in transplantation therapy for MI.
各种干细胞已被用于心脏修复。然而，任何单个的干细胞群体都没有被认为是理想的来源。最近，滋养层干细胞（TSC），一种新描述的干细胞类型，表现出广泛的可塑性。本研究评估了 TSC 移植治疗心肌梗死（MI）小鼠模型心脏再生的疗效，并与最常用的间充质干细胞（MSC）进行了直接比较。与 PBS 对照组相比，TSC 和 MSC 的移植导致心脏功能显著改善，但只有 TSC 表现出体内分化为心肌细胞的潜力。此外，在 TSC 组中观察到两种移植干细胞和内源性心肌细胞的增殖水平显著升高。这些发现初步揭示了 TSC 在 MI 移植治疗中的治疗潜力。
