DeFreitas Marissa J, Katsoufis Chryso P, Benny Merline, Young Karen, Kulandavelu Shathiyah, Ahn Hyunyoung, Sfakianaki Anna, Abitbol Carolyn L
Division of Pediatric Nephrology, Department of Pediatrics, University of Miami, Miami, FL, United States.
Department of Pediatrics, Batchelor Children's Research Institute, University of Miami, Miami, FL, United States.
Front Pediatr. 2022 Jun 30;10:853722. doi: 10.3389/fped.2022.853722. eCollection 2022.
Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.
当活性氧/活性氮与抗氧化系统之间失衡时，就会发生氧化应激。这些复杂过程之间的相互作用对正常妊娠和胎儿发育至关重要；然而，当氧化应激占主导时，就会出现与妊娠相关的并发症以及早产等不良胎儿编程情况。了解氧化应激如何对母婴二元组的结局产生负面影响，有助于探索抗氧化疗法来预防和/或减轻疾病进展。在发育中的肾脏中，氧化应激的负面影响也已被注意到，主要是在动物模型中，它与高血压和肾损伤的发生有关。关于氧化应激对发育中的肾脏影响的临床研究，不如对早产儿和其他脆弱新生儿群体的神经发育及呼吸状况的研究那么深入。采用团队科学方法研究围产期连续过程中的氧化应激途径，有助于了解母婴二元组所遭受的多器官功能障碍，并指导对抗氧化疗法的研究，以减轻整体毒性。这篇教育综述将提供一个全面的多学科视角，阐述围产期氧化应激对母婴并发症发生发展的影响，以及对加速衰老、心血管疾病和肾脏疾病终身发育编程的影响。
