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门体分流术作为婴儿肝移植的过渡手段:两种技术的比较。

Portosystemic shunt as a bridge to liver transplantation in infants: A comparison of two techniques.

作者信息

Yoeli Dor, Galván N Thao N, Ashton Daniel J, Kumm Kayla R, Kueht Michael L, Witte Ellen D, Miloh Tamir A, Cotton Ronald T, Rana Abbas, O'Mahony Christine A, Goss John A

机构信息

Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation and Hepatobiliary Surgery, Baylor College of Medicine, Houston, TX, USA.

Department of Surgery, Texas Children's Hospital, Houston, TX, USA.

出版信息

Pediatr Transplant. 2017 Jun;21(4). doi: 10.1111/petr.12915. Epub 2017 Mar 13.

Abstract

Portosystemic shunts can serve as a bridge to liver transplantation in patients with end-stage liver disease by providing portal decompression to treat life-threatening variceal bleeding and prevent recurrent episodes until an organ becomes available. The conventional TIPS procedure, however, is technically challenging to perform in infants due to the small size of their intrahepatic vasculature. We report two cases of emergent creation of portosystemic shunts as a bridge to liver transplantation in infants with life-threatening variceal bleeding using a conventional TIPS technique in the first case and a percutaneous DIPS technique in the other. Both procedures were successful at reducing the portosystemic pressure gradient and preventing further variceal bleeds until a liver transplant could be performed. The novel percutaneous DIPS procedure is a valuable alternative to the conventional TIPS in infants, as it is better suited for small or challenging intrahepatic vascular anatomy.

摘要

门体分流术可为终末期肝病患者提供门静脉减压,以治疗危及生命的静脉曲张出血,并预防复发,直至获得肝脏移植器官,从而作为肝移植的桥梁。然而,由于婴儿肝内血管系统较小,传统的经颈静脉肝内门体分流术(TIPS)在婴儿中实施技术上具有挑战性。我们报告了两例为有危及生命的静脉曲张出血的婴儿创建门体分流术作为肝移植桥梁的病例,第一例使用传统TIPS技术,另一例使用经皮直接门静脉-下腔静脉分流术(DIPS)技术。两种手术均成功降低了门体压力梯度,并防止了进一步的静脉曲张出血,直至能够进行肝移植。新型经皮DIPS手术是婴儿传统TIPS手术的一种有价值的替代方法,因为它更适合于小的或具有挑战性的肝内血管解剖结构。

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