Dalian Blood Center, Dalian, Liaoning, China.
Department of Cell Biology, Dalian Medical University, Dalian, China.
HLA. 2017 May;89(5):293-300. doi: 10.1111/tan.13006. Epub 2017 Mar 12.
The human leukocyte antigen (HLA) system is the most polymorphic gene cluster in humans. High-resolution donor-recipient matching for HLA genes improves patient survival after unrelated hematopoietic stem cell transplantation.
In this study, we analyzed the high-resolution allele and haplotype frequencies at the HLA-A, -B and -DRB1 loci in the Liaoning Han population and analyzed its relationships with other populations.
The 3 most frequent alleles at the HLA-A, -B and -DRB1 loci were A24:02, A02:01:01G, A11:01; B13:02, B46:01, B40:01:01G; DRB109:01, DRB115:01 and DRB107:01, respectively. The most frequent 2-locus haplotypes were A30:01-B13:02 and B13:02-DRB107:01. A30:01-B13:02-DRB107:01 was determined to be the predominant 3-locus haplotype. Hot maps and multiple correspondence analyses based on the frequencies of HLA specificities, which allow statistical visualization of dependent and independent relationships among variables, indicate that the Liaoning Han population is closely related to Northern populations of China and shows relative close relationships with Asian populations.
These data will provide an outline of the HLA characteristics of healthy individuals in our region and help bone marrow transplantation patients find suitable HLA-matched donors.
人类白细胞抗原（HLA）系统是人类最具多态性的基因簇。高分辨率的供受者 HLA 基因匹配可提高异基因造血干细胞移植后患者的生存率。
本研究分析了辽宁汉族人群 HLA-A、-B 和 -DRB1 基因座的高分辨率等位基因和单倍型频率，并分析了其与其他人群的关系。
HLA-A、-B 和 -DRB1 基因座最常见的 3 个等位基因为 A24:02、A02:01:01G、A11:01；B13:02、B46:01、B40:01:01G；DRB109:01、DRB115:01 和 DRB107:01。最常见的 2 个单倍型为 A30:01-B13:02 和 B13:02-DRB107:01。A30:01-B13:02-DRB107:01 被确定为主要的 3 个单倍型。基于 HLA 特异性频率的热点图和多元对应分析，允许对变量之间的依赖和独立关系进行统计可视化，表明辽宁汉族人群与中国北方人群密切相关，并与亚洲人群有相对密切的关系。
这些数据将为我们地区健康个体的 HLA 特征提供概述，并有助于骨髓移植患者找到合适的 HLA 匹配供体。
