Tissue Typing Center, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia.
Int J Immunogenet. 2014 Jun;41(3):211-21. doi: 10.1111/iji.12117. Epub 2014 Apr 25.
The determination of human leucocyte antigen (HLA)-A, HLA-B and HLA-DRB1 alleles in the routine procedure of a volunteer hematopoietic stem cell (HSC) donor's registration in the Croatian Bone Marrow Donor Registry (CBMDR) is performed to enhance the odds of finding a suitable HLA compatible donor for patients in need of a HSC transplantation worldwide. However, besides its original purpose, it also provides valuable information about the HLA polymorphism among Croats. The aim of the present study was to analyse the HLA allele and haplotype frequencies in a sample of 4000 donors from CBMDR. The distribution of HLA-A, HLA-B and HLA-DRB1 alleles did not demonstrate significant differences from the data reported for other European populations. The higher frequency of B40:02 allele in comparison with B40:01 and DRB111:04 in comparison with DRB111:01 is interesting because it represents a difference in comparison with the Western and Northern European populations which are a main source of donors for Croatian patients. The haplotype frequencies show a greater variation and difference in comparison with data from other registries and populations; however, due to a lack of high-resolution haplotype data, comparison was possible only with a very limited number of other populations.
在克罗地亚骨髓捐献者登记处（CBMDR）的志愿者造血干细胞（HSC）捐献者登记的常规程序中，测定人类白细胞抗原（HLA）-A、HLA-B 和 HLA-DRB1 等位基因，以增加为全球需要 HSC 移植的患者找到合适 HLA 相容供体的几率。然而，除了其最初的目的之外，它还提供了有关克罗地亚人 HLA 多态性的有价值信息。本研究的目的是分析来自 CBMDR 的 4000 名供体样本中的 HLA 等位基因和单倍型频率。HLA-A、HLA-B 和 HLA-DRB1 等位基因的分布与其他欧洲人群报告的数据没有显著差异。与 B40:01 相比，B40:02 等位基因和与 DRB111:01 相比，DRB111:04 等位基因的更高频率很有趣，因为它与西方和北欧人群存在差异，这些人群是克罗地亚患者供体的主要来源。与其他登记处和人群的数据相比，单倍型频率显示出更大的差异和变化；然而，由于缺乏高分辨率的单倍型数据，仅与非常有限的其他人群进行了比较。
