The distribution of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes based on high-resolution genotyping of 167 families from Jiangsu Province, China.

We investigated the human leukocyte antigen (HLA)-A, -B, and -DRB1 allele frequencies, the A-B-DRB1, A-B, B-DRB1, and A-DRB1 haplotype frequencies, and the characteristics of linkage disequilibrium between 2 loci in high resolution based on 167 unrelated families from Jiangsu Province, China. A total of 26 alleles at the A locus, 55 alleles at the B locus, and 34 alleles at the DRB1 locus were reported in this study. The top 5 most frequent HLA alleles at the HLA-A, -B, and -DRB1 loci, respectively, were A11:01, A24:02, A02:01, A33:03, A30:01; B13:02, B40:01 B46:01, B58:01, B54:01; DRB109:01, DRB107:01, DRB112:02, DRB115:01, and DRB108:03. Several haplotypes with high frequencies were deduced in this study. The top 3 most common A-B-DRB1 haplotypes observed were A30:01-B13:02-DRB107:01, A33:03-B58:01-DRB103:01, and A02:07-B46:01-DRB109:01. The top 3 most common A-B haplotypes were A30:01-B13:02, A33:03-B58:01, and A02:07-B46:01. The top 4 most common A-DRB1 haplotypes were A30:01-DRB107:01, A33:03-DRB113:02, A24:02-DRB109:01, and A33:03-DRB103:01. Finally, the top 3 most common B-DRB1 haplotypes were B13:02-DRB107:01, B46:01-DRB109:01, and B58:01-DRB103:01. From the linkage disequilibrium calculation, the most prominent associations were A30:01-B13:02, B13:02-DRB107:01, and A01:03-DRB101:02. These allele and haplotype frequencies could be useful for finding the best matched donors for patients in the China Marrow Donor Program Jiangsu Branch.