Qiu Hui, Min Yuanzeng, Rodgers Zach, Zhang Longzhen, Wang Andrew Z
Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine; Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.
Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Sep;9(5). doi: 10.1002/wnan.1456. Epub 2017 Mar 10.
Significant advances have been made in the field of cancer immunotherapy by orchestrating the body's immune system to eradicate cancer cells. However, safety and efficacy concerns stemming from the systemic delivery of immunomodulatory compounds limits cancer immunotherapies expansion and application. In this context, nanotechnology presents a number of advantages, such as targeted delivery to immune cells, enhanced clinical outcomes, and reduced adverse events, which may aid in the delivery of cancer vaccines and immunomodulatory agents. With this in mind, a diverse range of nanomaterials with different physicochemical characteristics have been developed to stimulate the immune system and battle cancer. In this review, we will focus on some recent developments and the potential advantages of utilizing nanotechnology within the field of cancer immunotherapy. WIREs Nanomed Nanobiotechnol 2017, 9:e1456. doi: 10.1002/wnan.1456 For further resources related to this article, please visit the WIREs website.
通过调控人体免疫系统来根除癌细胞，癌症免疫疗法领域已取得了重大进展。然而，免疫调节化合物全身给药引发的安全性和有效性问题限制了癌症免疫疗法的扩展和应用。在此背景下，纳米技术具有诸多优势，如靶向递送至免疫细胞、提高临床疗效以及减少不良事件，这可能有助于癌症疫苗和免疫调节药物的递送。考虑到这一点，人们已开发出多种具有不同物理化学特性的纳米材料来刺激免疫系统并对抗癌症。在本综述中，我们将聚焦于癌症免疫疗法领域中纳米技术的一些最新进展及潜在优势。《WIREs纳米医学与纳米生物技术》2017年，9:e1456。doi:10.1002/wnan.1456 欲获取与本文相关的更多资源，请访问WIREs网站。
