Streeter Chris C, Gerbarg Patricia L, Whitfield Theodore H, Owen Liz, Johnston Jennifer, Silveri Marisa M, Gensler Marysia, Faulkner Carol L, Mann Cathy, Wixted Mary, Hernon Anne Marie, Nyer Maren B, Brown E Richard P, Jensen John E
1 Department of Psychiatry, Boston University School of Medicine , Boston, MA.
2 Department of Neurology, Boston University School of Medicine , Boston, MA.
J Altern Complement Med. 2017 Mar;23(3):201-207. doi: 10.1089/acm.2016.0140. Epub 2017 Feb 16.
The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD).
Subjects were randomized to the high-dose group (HDG) or low-dose group (LDG) for a 12-week intervention of three or two intervention classes per week, respectively. Eligible subjects were 18-64 years old with MDD, had baseline Beck Depression Inventory-II (BDI-II) scores ≥14, and were either on no antidepressant medications or on a stable dose of antidepressants for ≥3 months. The intervention included 90-min classes plus homework. Outcome measures were BDI-II scores and intervention compliance.
Fifteen HDG (M = 38.4 ± 15.1 years) and 15 LDG (M = 34.7 ± 10.4 years) subjects completed the intervention. BDI-II scores at screening and compliance did not differ between groups (p = 0.26). BDI-II scores declined significantly from screening (24.6 ± 1.7) to week 12 (6.0 ± 3.8) for the HDG (-18.6 ± 6.6; p < 0.001), and from screening (27.7 ± 2.1) to week 12 (10.1 ± 7.9) in the LDG (-17.7 ± 9.3; p < 0.001). There were no significant differences between groups, based on response (i.e., >50% decrease in BDI-II scores; p = 0.65) for the HDG (13/15 subjects) and LDG (11/15 subjects) or remission (i.e., number of subjects with BDI-II scores <14; p = 1.00) for the HDG (14/15 subjects) and LDG (13/15 subjects) after the 12-week intervention, although a greater number of subjects in the HDG had 12-week BDI-II scores ≤10 (p = 0.04).
During this 12-week intervention of yoga plus coherent breathing, depressive symptoms declined significantly in patients with MDD in both the HDG and LDG. Both groups showed comparable compliance and clinical improvements, with more subjects in the HDG exhibiting BDI-II scores ≤10 at week 12.
本研究旨在评估艾扬格瑜伽干预及每分钟五次连贯呼吸对抑郁症状的影响，并确定针对重度抑郁症（MDD）患者未来研究的最佳干预瑜伽剂量。
将受试者随机分为高剂量组（HDG）或低剂量组（LDG），分别进行为期12周的干预，高剂量组每周参加三节干预课程，低剂量组每周参加两节干预课程。符合条件的受试者年龄在18至64岁之间，患有MDD，贝克抑郁量表第二版（BDI-II）基线得分≥14，且未服用抗抑郁药物或已稳定服用抗抑郁药物≥3个月。干预包括90分钟的课程及家庭作业。观察指标为BDI-II得分及干预依从性。
15名高剂量组受试者（平均年龄M = 38.4 ± 15.1岁）和15名低剂量组受试者（平均年龄M = 34.7 ± 10.4岁）完成了干预。两组在筛查时的BDI-II得分及依从性无差异（p = 0.26）。高剂量组的BDI-II得分从筛查时的（24.6 ± 1.7）显著下降至第12周时的（6.0 ± 3.8）（-18.6 ± 6.6；p < 0.001），低剂量组从筛查时的（27.7 ± 2.1）下降至第12周时的（10.1 ± 7.9）（-17.7 ± 9.3；p < 0.001）。基于反应（即BDI-II得分下降>50%），高剂量组（13/15名受试者）和低剂量组（11/15名受试者）之间无显著差异（p = 0.65）；基于缓解情况（即BDI-II得分<14的受试者数量），12周干预后高剂量组（14/15名受试者）和低剂量组（13/15名受试者）之间也无显著差异（p = 1.00），尽管高剂量组中有更多受试者在第12周时BDI-II得分≤10（p = 0.04）。
在为期12周的瑜伽加连贯呼吸干预期间，高剂量组和低剂量组的MDD患者抑郁症状均显著下降。两组的依从性和临床改善情况相当，高剂量组中有更多受试者在第12周时BDI-II得分≤10。
