Villar Victor H, Durán Raúl V
a Institut Européen de Chimie et Biologie, ACTION Unit U1218, INSERM and University of Bordeaux , Pessac , France.
Autophagy. 2017 Jun 3;13(6):1078-1079. doi: 10.1080/15548627.2017.1299315. Epub 2017 Mar 15.
Glutaminolysis plays a critical role in nutrient sufficiency and cell signaling activation in mammalian cells. Unexpectedly, our recent investigations revealed that the unbalanced activation of glutaminolysis during nutritional restriction causes a particular form of apoptotic cell death, that we termed "glutamoptosis." We found that the inhibition of autophagy is a key step to allow glutamoptosis-mediated cell death. Thus, autophagy controls glutamoptosis during nutritional imbalance.
谷氨酰胺分解在哺乳动物细胞的营养充足和细胞信号激活中起着关键作用。出乎意料的是，我们最近的研究表明，营养限制期间谷氨酰胺分解的失衡激活会导致一种特殊形式的凋亡性细胞死亡，我们将其称为“谷氨酰胺凋亡”。我们发现抑制自噬是使谷氨酰胺凋亡介导的细胞死亡发生的关键步骤。因此，自噬在营养失衡期间控制谷氨酰胺凋亡。
