Elowe Sabine
a Department de Pédiatrie, Faculté de Medicine , Université Laval, Axe de Réproduction, Santé de la Mère et de l'enfant, Centre de Rechereche du CHU de Québec , Québec , QC , Canada.
Cell Cycle. 2017 Apr 18;16(8):746-748. doi: 10.1080/15384101.2017.1302632. Epub 2017 Mar 15.
Tyrosine phosphorylation is rare, representing only about 0.5% of phosphorylations in the cell under basal conditions. While mitogenic tyrosine kinase signaling has been extensively explored, the role of phosphotyrosine signaling across the cell cycle and in particular during mitosis is poorly understood. Two recent, independent studies tackled this question from different angles to reveal exciting new insights into the role of this modification during cell division. Caron et al. exploited mitotic phosphoproteomics data sets to determine the extent of mitotic tyrosine phosphorylation, and St-Denis et al. identified protein tyrosine phosphatases from all subfamilies as regulators of mitotic progression or spindle formation. These studied collectively revealed that tyrosine phosphorylation may play a more prominent and active role in mitotic progression than previously appreciated.
酪氨酸磷酸化很少见，在基础条件下仅占细胞内磷酸化的约0.5%。虽然有丝分裂原性酪氨酸激酶信号传导已得到广泛研究，但磷酸酪氨酸信号在整个细胞周期，特别是在有丝分裂过程中的作用却知之甚少。最近两项独立研究从不同角度解决了这个问题，揭示了这种修饰在细胞分裂过程中作用的令人兴奋的新见解。卡龙等人利用有丝分裂磷酸蛋白质组学数据集来确定有丝分裂酪氨酸磷酸化的程度，而圣丹尼斯等人则将所有亚家族的蛋白质酪氨酸磷酸酶鉴定为有丝分裂进程或纺锤体形成的调节因子。这些研究共同表明，酪氨酸磷酸化在有丝分裂进程中可能发挥比以前认识到的更突出和更积极的作用。
