Wen Hongwei, Wang Lijuan
Department of Physical Education, Shanghai University of Finance and Economics School of Physical Education and Sports Training, Shanghai University of Sport, Shanghai, China.
Medicine (Baltimore). 2017 Mar;96(11):e6150. doi: 10.1097/MD.0000000000006150.
The comprehensive meta-analysis aimed to explore the reductive effect of aerobic exercise on blood pressure of hypertensive patients.
The related researches were selected from PubMed and Embase databases up to June 2016. Based on specific inclusive criteria, the eligible studies were selected, and the heterogeneities in their results were estimated by χ-based Q-test and I statistics. Quantitative meta-analysis was assessed by R 3.12 software, and results were presented by standardized mean difference (SMD) and their 95% confidence intervals (CIs). Outcome indicators were systolic blood pressure (SBP) and diastolic blood pressure (DBP). The publication biases were estimated by Egger test. Besides, the "leave one out" method was used for sensitivity evaluations.
As a result, a total of 13 papers with 802 samples were included. Based on the meta-analysis results, there were no significant differences in SBP and DBP between aerobic and control groups before exercise (SMD = 0.15, 95%CI: -0.16-0.46; SMD = 0.16, 95% CI: -0.23-0.55). However, significant reductions were obviously in aerobic group after aerobics, compared with control (SMD = -0.79, 95% CI: -1.29 to -0.28; SMD = -0.63, 95% CI: -1.14 to -0.12). A significant publication bias was detected in SBP (t = -2.2314, P = 0.04549) but not in DBP (t = -1.4962, P = 0.1604). Additionally, the DBP result would be altered after the exclusion of 2 individual papers.
Aerobic exercise may be a potential nonpharmacological treatment for blood pressure improvement in essential hypertensive patients.
本综合荟萃分析旨在探讨有氧运动对高血压患者血压的降低作用。
从PubMed和Embase数据库中检索截至2016年6月的相关研究。根据特定的纳入标准选择符合条件的研究，并通过基于χ²的Q检验和I²统计量评估其结果的异质性。使用R 3.12软件进行定量荟萃分析，结果以标准化均值差（SMD）及其95%置信区间（CI）表示。结局指标为收缩压（SBP）和舒张压（DBP）。通过Egger检验评估发表偏倚。此外，采用“逐一排除”法进行敏感性评估。
共纳入13篇文献，802个样本。基于荟萃分析结果，有氧运动组和对照组在运动前SBP和DBP无显著差异（SMD = 0.15，95%CI：-0.16 - 0.46；SMD = 0.16，95%CI：-0.23 - 0.55）。然而，与对照组相比，有氧运动组在有氧运动后SBP和DBP均显著降低（SMD = -0.79，95%CI：-1.29至-0.28；SMD = -0.63，95%CI：-1.14至-0.12）。在SBP中检测到显著的发表偏倚（t = -2.2314，P = 0.04549），而在DBP中未检测到（t = -1.4962，P = 0.1604）。此外，排除2篇个体文献后DBP结果会发生改变。
有氧运动可能是改善原发性高血压患者血压的一种潜在非药物治疗方法。
