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2016年自身免疫性肝病的研究进展

[Research advances in autoimmune liver diseases in 2016].

作者信息

Li B, Wang Q X, Ma X

机构信息

Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2017 Feb 20;25(2):100-104. doi: 10.3760/cma.j.issn.1007-3418.2017.02.004.

Abstract

Autoimmune liver diseases are a group of abnormal autoimmune-mediated inflammatory hepatobiliary injuries, mainly including autoimmune hepatitis(AIH), primary biliary cholangitis(PBC), and primary sclerosing cholangitis (PSC). The diagnosis and treatment of autoimmune liver diseases, an important type of non-viral liver disease, have become a prominent issue in hepatology. In 2016, many new advances have been achieved in the clinical and basic research on autoimmune liver diseases, including the phase 3 clinical trial of obeticholic acid, the proposal of UK-PBC risk score, and the research on gut microbiota associated with PSC. This article reviews the research advances in the diagnosis and treatment of autoimmune liver diseases in 2016.

摘要

自身免疫性肝病是一组由异常自身免疫介导的炎症性肝胆损伤疾病,主要包括自身免疫性肝炎(AIH)、原发性胆汁性胆管炎(PBC)和原发性硬化性胆管炎(PSC)。自身免疫性肝病作为非病毒性肝病的一种重要类型,其诊断和治疗已成为肝病学领域的一个突出问题。2016年,自身免疫性肝病的临床和基础研究取得了许多新进展,包括奥贝胆酸的3期临床试验、英国PBC风险评分的提出以及与PSC相关的肠道微生物群研究。本文综述了2016年自身免疫性肝病诊断和治疗方面的研究进展。

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