Yang F Y, Wo W H
Institute of Biophysics, Academia Sinica, Beijing, China.
Biochem Int. 1987 Aug;15(2):475-82.
Na2SeO3 supplementation in the ageing medium could protect aged erythrocyte ghosts from decreases in lipid fluidity, Na, K-ATPase activity, and sensitivity to ouabain. Results also showed that Se could obviously prevent the dissociation of spectrin from the erythrocyte membrane. Furthermore, Se could markedly promote the reassociation of spectrin with the spectrin-stripped inside out membrane vesicles(IOVs) of erythrocytes. The protective action of Se on biomembranes is generally interpreted in terms of the activity of Se-containing glutathione peroxidase (GSHPx). However, since GSHPx is mainly distributed in the cytoplasm of erythrocytes, the stabilizing effect of Se on erythrocyte membranes might not be related to the activity of this enzyme.
在老化培养基中添加亚硒酸钠可以保护衰老的红细胞膜免受脂质流动性降低、钠钾 - ATP酶活性降低以及对哇巴因敏感性降低的影响。结果还表明，硒可以明显防止血影蛋白从红细胞膜上解离。此外，硒可以显著促进血影蛋白与红细胞的血影蛋白剥离的外翻膜囊泡（IOV）重新结合。硒对生物膜的保护作用通常根据含硒谷胱甘肽过氧化物酶（GSHPx）的活性来解释。然而，由于GSHPx主要分布在红细胞的细胞质中，硒对红细胞膜的稳定作用可能与该酶的活性无关。
