Njunda Anna L, Nsagha Dickson S, Assob Jules C N, Palle John N, Kamga Henri L, Nde Peter F, Ntube Mengang N C, Weledji Patrick E
Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea.
Department of Public Health and Hygiene, Faculty of Health Sciences, University of Buea.
J Public Health Afr. 2011 Mar 3;2(1):e16. doi: 10.4081/jphia.2011.e16. eCollection 2011 Mar 1.
Genital mycoplasmas are implicated in pelvic inflammatory diseases, puerperal infection, septic abortions, low birth weight, nongonococcal urethritis and prostatitis as well as spontaneous abortion and infertility in women. There is paucity of data on colonisation of genital mycoplasma in women and their drug sensitivity patterns. The aim of our study was to determine the prevalence of genital mycoplasmas ( and ) infection and their drug sensitivity patterns in women. A mycofast kit was used for biochemical determination of mycoplasma infection in 100 randomly selected female patients aged 19-57 years, attending the University of Yaoundé Teaching Hospital (UYTH) from March to June 2010. Informed consent was sought and gained before samples were collected. Genital mycoplasmas were found in 65 patients (65%) [95% CI=55.7-74.3%] and distributed as 41 (41%) [95% CI=31.4-50.6%] for and 4 (4%) [95% CI=0.20- 7.8%] for while there was co-infection in 20 women (20%) [95% CI=12.16-27.84%]. In our study, 57 (57%) [95% CI=47.3-67%] had other organisms, which included (19 [19%]), (35 [35%]) and (3 [3%]). Among the 65 women with genital mycoplasma, the highest co-infection was with (33.8%). Pristinamycine was the most effective antibiotic (92%) and sulfamethoxazole the most resistant (8%) antibiotic to genital mycoplasmas. We conclude that genital mycoplasma is a problem in Cameroon and infected women should be treated together with their partners.
生殖支原体与盆腔炎性疾病、产褥感染、感染性流产、低出生体重、非淋菌性尿道炎和前列腺炎以及女性自然流产和不孕有关。关于女性生殖支原体定植及其药敏模式的数据较少。我们研究的目的是确定女性生殖支原体(和解脲脲原体)感染的患病率及其药敏模式。2010年3月至6月期间,在雅温得大学教学医院(UYTH)就诊的100名年龄在19至57岁之间的随机选择的女性患者中,使用Mycofast试剂盒对支原体感染进行生化测定。在采集样本之前,已寻求并获得了知情同意。65名患者(65%)[95%置信区间=55.7 - 74.3%]检测到生殖支原体,其中人型支原体为41例(41%)[95%置信区间=31.4 - 50.6%],解脲脲原体为4例(4%)[95%置信区间=0.20 - 7.8%],20名女性(20%)[95%置信区间=12.16 - 27.84%]存在合并感染。在我们的研究中,57例(57%)[95%置信区间=47.3 - 67%]患者感染了其他病原体,其中包括沙眼衣原体(19例[19%])、淋病奈瑟菌(35例[35%])和白色念珠菌(3例[3%])。在65例感染生殖支原体的女性中,合并感染率最高的是沙眼衣原体(33.8%)。普那霉素是对生殖支原体最有效的抗生素(92%),而磺胺甲恶唑是最耐药的抗生素(8%)。我们得出结论,生殖支原体在喀麦隆是一个问题,感染的女性应与其伴侣一起接受治疗。