Cormier Kevin W, Woodgett James R
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.
F1000Res. 2017 Feb 20;6. doi: 10.12688/f1000research.10557.1. eCollection 2017.
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood disorders to diabetes to neurodegenerative diseases and cancers. The selectivity and insulation of such a promiscuous kinase from unwanted crosstalk between pathways, while orchestrating a multifaceted response to cellular stimuli, offer key insights into more general mechanisms of cell regulation. Here, we review recent advances that have contributed to the understanding of GSK-3 and its role in driving appreciation of intracellular signal coordination.
糖原合酶激酶-3（GSK-3）是一种广泛表达的蛋白激酶，处于多种信号通路的核心位置。它深度融入细胞控制回路，这与其在从情绪障碍到糖尿病、神经退行性疾病和癌症等多种疾病中的作用密切相关。在协调细胞对刺激的多方面反应时，这种多用途激酶如何避免与其他通路产生不必要的串扰，实现选择性和隔离性，这为更普遍的细胞调节机制提供了关键见解。在此，我们综述了近期的研究进展，这些进展有助于理解GSK-3及其在促进细胞内信号协调方面的作用。
