Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany.
Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany.
Trends Cell Biol. 2016 Dec;26(12):956-967. doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24.
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
Wnt/LRP6 信号通路以 β-连环蛋白依赖性调控靶基因而闻名。然而，最近出现了分支途径，包括 Wnt/STOP 信号通路，其独立于 β-连环蛋白和转录作用。本文综述了β-连环蛋白非依赖性 Wnt/LRP6 信号级联的分子机制及其对细胞生物学、发育和生理学的影响。
