Shapiro Michael D, Fazio Sergio
Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
F1000Res. 2017 Feb 13;6:134. doi: 10.12688/f1000research.9845.1. eCollection 2017.
Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.
富含胆固醇、载脂蛋白B（apoB）的脂蛋白如今已被广泛认为是动脉粥样硬化性心血管疾病最重要的致病因素。多条明确且相互独立的证据都指向低密度脂蛋白及相关颗粒是动脉粥样硬化发生过程中的主要参与者。在此，我们综述了致动脉粥样硬化的含apoB脂蛋白在心血管疾病中的基础作用，以及启动和维持动脉退变所需的其他几个体液和壁层因素。还简要综述了泡沫细胞的生物学特性及其与高密度脂蛋白的相互作用，包括胆固醇流出。
