Kazan State Medical University, Kazan, Russia.
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
J Immunol Res. 2017;2017:9829436. doi: 10.1155/2017/9829436. Epub 2017 Feb 19.
Serum cytokine levels were explored in a combined group of patients with autoimmune liver diseases (AILDs) and separately in patients with autoimmune hepatitis (AIH) and overlap syndrome. Overall, 60 patients with AILD, among them 32 patients with AIH and 28 patients with overlap syndrome, were included in the cross-sectional study. Serum cytokine levels were measured at baseline and compared to those of 21 healthy controls. Patients with AILD had significantly higher levels of IL-6 (0.70 (range 0.17-99.86) in patients with AILD compared to 0.40 (range 0.14-2.65) in controls, < 0.01), IL-8 (1.66 (0.45-34.58) versus 0.53 (0.35-2.38), resp., < 0.01), and TNF- (2.61 (0.23-120.88) versus 1.65 (0.21-7.54), resp., < 0.01). Adjusted logistic regression analysis revealed a pronounced relation of IL-8 and AILD, 48.36 (3.63-643.60), as well as AIH, 18.54 (1.08-318.54), and overlap syndrome, 23.85 (2.37-240.23), while the associations between the level of other cytokines and AILD were assessed as nonsignificant. In the language of absolute numbers, the increase of IL-8 serum level by 1 pg/mL had increased the chance for a patient to find himself in a group of AILD by 48.36 times. Also, high IL-8 serum levels were strongly related to clinical parameters.
在自身免疫性肝病（AILD）患者的综合组中以及在自身免疫性肝炎（AIH）患者和重叠综合征患者中分别探讨了血清细胞因子水平。这项横断面研究共纳入 60 名 AILD 患者，其中 32 名 AIH 患者和 28 名重叠综合征患者。在基线时测量了血清细胞因子水平，并与 21 名健康对照者进行了比较。AILD 患者的 IL-6 水平明显升高（AILD 患者为 0.70（范围 0.17-99.86），而对照组为 0.40（范围 0.14-2.65），<0.01）、IL-8（1.66（0.45-34.58）比对照组 0.53（0.35-2.38），<0.01）和 TNF-（2.61（0.23-120.88）比对照组 1.65（0.21-7.54），<0.01）。调整后的逻辑回归分析显示，IL-8 与 AILD 显著相关，OR 为 48.36（3.63-643.60），与 AIH 也显著相关，OR 为 18.54（1.08-318.54），与重叠综合征也显著相关，OR 为 23.85（2.37-240.23），而其他细胞因子水平与 AILD 的相关性被评估为无统计学意义。从绝对值来看，IL-8 血清水平增加 1 pg/mL，患者患 AILD 的几率增加 48.36 倍。此外，高 IL-8 血清水平与临床参数密切相关。
