Runx1在胚胎血细胞形成中的作用。
The Role of Runx1 in Embryonic Blood Cell Formation.
作者信息
Yzaguirre Amanda D, de Bruijn Marella F T R, Speck Nancy A
机构信息
Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19103, USA.
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, UK.
出版信息
Adv Exp Med Biol. 2017;962:47-64. doi: 10.1007/978-981-10-3233-2_4.
Abstract
The de novo generation of hematopoietic stem and progenitor cells (HSPC) occurs solely during embryogenesis from a population of epithelial cells called hemogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic vascular beds leave the vessel wall as they transition into HSPCs in a process termed the endothelial to hematopoietic transition (EHT). Runx1 expression in HE cells orchestrates the transcriptional switch necessary for the transdifferentiation of endothelial cells into functional HSPCs. Runx1 is widely considered the master regulator of developmental hematopoiesis because it plays an essential function during specification of the hematopoietic lineage during embryogenesis. Here we review the role of Runx1 in embryonic HSPC formation, with a particular focus on its role in hemogenic endothelium.
摘要
造血干细胞和祖细胞（HSPC）的从头生成仅在胚胎发育期间从一群称为造血内皮（HE）的上皮细胞中发生。在妊娠中期，多个胚胎内和胚胎外血管床中的HE细胞在向内皮-造血转化（EHT）过程中转变为HSPC时离开血管壁。HE细胞中Runx1的表达协调了内皮细胞转分化为功能性HSPC所需的转录开关。Runx1被广泛认为是发育性造血的主要调节因子，因为它在胚胎发育期间造血谱系的特化过程中发挥着重要作用。在这里，我们综述了Runx1在胚胎HSPC形成中的作用，特别关注其在造血内皮中的作用。
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Dev Dyn. 2016 Oct;245(10):1011-28. doi: 10.1002/dvdy.24430. Epub 2016 Aug 17.
2
The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development.在胚胎发育过程中，内皮祖细胞的造血能力受到Runx1基因沉默的限制。
Cell Rep. 2016 Jun 7;15(10):2185-2199. doi: 10.1016/j.celrep.2016.05.001. Epub 2016 May 26.
3
Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head.小鼠胚胎头部中表达Ly6aGFP的造血细胞的亚区域定位与特征分析
Dev Biol. 2016 Aug 1;416(1):34-41. doi: 10.1016/j.ydbio.2016.05.031. Epub 2016 May 25.
4
Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver.未成熟前体细胞的隐匿性扩增是胎儿肝脏中成年造血干细胞活性急性爆发的基础。
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6
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Nat Cell Biol. 2016 Jan;18(1):21-32. doi: 10.1038/ncb3276. Epub 2015 Nov 30.
7
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8
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Development. 2015 Aug 1;142(15):2719-24. doi: 10.1242/dev.121350.
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