Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.
Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Nov;9(6). doi: 10.1002/wnan.1466. Epub 2017 Mar 16.
With continued advancements in nanoparticle (NP) synthesis and in the interfacing of NPs with biological systems has come the exponential growth in the use of NPs for therapeutic drug delivery and imaging applications. In recent years, the advent of NP multifunctionality-the ability to perform multiple, disparate functions on a single NP platform-has garnered much excitement for the potential realization of highly functional NP-mediated drug delivery for use in the clinical setting. This Overview will survey the current state of the art (reports published within the last 5 years) of multifunctional NPs for therapeutic drug delivery, imaging or a combination thereof. We provide extensive examples of both soft (micelles, liposomes, polymeric NPs) and hard (noble metals, quantum dots, metal oxides) NP formulations that have been used for multimodal drug delivery and imaging. The criteria for inclusion, herein, is that there must be at least two therapeutic drug cargos or imaging agents or a combination of the two. We next offer an assessment of the cytotoxicity of therapeutic NP constructs in biological systems. We then conclude with a forward-looking perspective on how we expect this field to develop in the coming years. WIREs Nanomed Nanobiotechnol 2017, 9:e1466. doi: 10.1002/wnan.1466 For further resources related to this article, please visit the WIREs website.
随着纳米粒子（NP）合成技术的不断进步以及 NP 与生物系统的接口技术的不断进步，NP 在治疗性药物输送和成像应用中的应用呈指数级增长。近年来，NP 的多功能性——即在单个 NP 平台上执行多种不同功能的能力——为实现高度功能性的 NP 介导的药物输送在临床环境中的应用带来了极大的兴奋。本综述将调查用于治疗性药物输送、成像或两者结合的多功能 NP 的最新技术状态（在过去 5 年内发表的报告）。我们提供了广泛的软（胶束、脂质体、聚合物 NP）和硬（贵金属、量子点、金属氧化物）NP 制剂的例子，这些制剂已被用于多模式药物输送和成像。这里的纳入标准是，必须至少有两种治疗性药物载体或成像剂，或两者的组合。接下来，我们对生物系统中治疗性 NP 构建体的细胞毒性进行了评估。最后，我们对未来几年该领域的发展进行了前瞻性展望。WIREs Nanomed Nanobiotechnol 2017, 9:e1466. doi: 10.1002/wnan.1466 如需与此文章相关的更多资源，请访问 WIREs 网站。
