ETS转录因子对DNA靶标的选择性特征
Signatures of DNA target selectivity by ETS transcription factors.
作者信息
Poon Gregory M K, Kim Hye Mi
机构信息
a Department of Chemistry , Georgia State University , Atlanta , GA , USA.
b Center for Diagnostics and Therapeutics, Georgia State University , Atlanta , GA , USA.
出版信息
Transcription. 2017 May 27;8(3):193-203. doi: 10.1080/21541264.2017.1302901. Epub 2017 Mar 16.
Abstract
The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.
摘要
ETS转录因子家族是一组功能异质性的基因调节因子，它们共享一个结构保守的、以该家族命名的DNA结合结构域。DNA靶标特异性源于与其他蛋白质的组合相互作用以及ETS结构域之间的内在异质性。新出现的证据表明，分子水合作用是定义DNA靶标选择中的内在异质性以及对表观遗传DNA修饰敏感性的一个基本特征。这一观点引发了关于生理渗透应激中ETS蛋白调控、它们在异染色质中的开拓潜力以及被动和药物性DNA去甲基化对ETS调控影响的新假设。
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