Webster C, Kempsell K, Booth I, Busby S
Department of Biochemistry, University of Birmingham, U.K.
Gene. 1987;59(2-3):253-63. doi: 10.1016/0378-1119(87)90333-7.
The regulatory region of the Escherichia coli melibiose operon contains two divergent promoters. One promoter is responsible for the expression of the melR gene, that is essential for melibiose-dependent stimulation of the second promoter. Melibiose-induced transcription from this second promoter initiates at a start point 25 bp upstream from the start codon of the melA gene, encoding an alpha-galactosidase. The nucleotide sequence covering the divergent promoters and the melR gene is reported.
大肠杆菌蜜二糖操纵子的调控区域包含两个方向相反的启动子。一个启动子负责melR基因的表达，该基因对于蜜二糖依赖型刺激第二个启动子至关重要。来自第二个启动子的蜜二糖诱导转录起始于melA基因（编码一种α-半乳糖苷酶）起始密码子上游25 bp处的一个起始点。报道了涵盖这两个方向相反的启动子和melR基因的核苷酸序列。
