Sun Yanwei, Wang Yibing, Li Liang, Zhang Zheng, Wang Ning, Wu Dan
1 Department of Burns & Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
2 Department of Burns & Plastic Surgery, Central Hospital of Zibo, Zibo, Shandong Province, China.
J Cutan Med Surg. 2017 Jul/Aug;21(4):316-319. doi: 10.1177/1203475417697652. Epub 2017 Mar 16.
Discontinuation of aspirin therapy before cutaneous surgery may cause serious complications.
The aim of this prospective study was to evaluate the bleeding risk of split-thickness skin transplantation repair to chronic wounds in patients on aspirin therapy.
A total of 97 patients who underwent split-thickness skin transplantation surgery of chronic wounds during a 2-year period were enrolled. They were categorized on the basis of aspirin therapies. The primary outcome was postoperative bleeding and bleeding complications. Univariate analysis was performed to examine the association between aspirin and bleeding complications. Among the 26 patients taking aspirin continuously in group A, there were 5 bleeding complications (19.23%). Among the 55 nonusers in group B, there were 10 bleeding complications (18.18%). Among the 16 discontinuous patients in group C, there were 3 bleeding complications (18.75%). No statistical differences were found among the groups ( P = .956). Univariate analysis showed that continuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.933; 95% confidence interval, 0.283-3.074; P = .910 in the aspirin and control groups) and that discontinuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.963; 95% confidence interval, 0.230-4.025; P = .959 in the aspirin and control groups; odds ratio, 0.969; 95% confidence interval, 0.198-4.752; P = .969 in the aspirin and discontinuous groups).
Continuous aspirin use does not produce an additional bleeding risk in patients who undergo split-thickness skin transplantation repair of chronic wounds.
皮肤手术前停用阿司匹林治疗可能会导致严重并发症。
这项前瞻性研究的目的是评估接受阿司匹林治疗的患者进行慢性伤口的中厚皮片移植修复时的出血风险。
纳入了在两年期间接受慢性伤口中厚皮片移植手术的97例患者。他们根据阿司匹林治疗情况进行分类。主要结局是术后出血和出血并发症。进行单因素分析以检验阿司匹林与出血并发症之间的关联。A组中持续服用阿司匹林的26例患者中有5例出血并发症（19.23%）。B组中55例未服用者中有10例出血并发症（18.18%）。C组中16例间断服用者中有3例出血并发症（18.75%）。各组之间未发现统计学差异（P = 0.956）。单因素分析显示，持续使用阿司匹林与出血并发症无显著关联（比值比，0.933；95%置信区间，0.283 - 3.074；阿司匹林组与对照组比较，P = 0.910），间断使用阿司匹林与出血并发症也无显著关联（比值比，0.963；95%置信区间，0.230 - 4.025；阿司匹林组与对照组比较，P = 0.959；比值比，0.969；95%置信区间，0.198 - 4.752；阿司匹林组与间断服用组比较，P = 0.969）。
对于接受慢性伤口中厚皮片移植修复的患者，持续使用阿司匹林不会产生额外的出血风险。
