Zheng Vera Zhiyuan, Wong George Kwok Chu
Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
J Clin Neurosci. 2017 Aug;42:7-11. doi: 10.1016/j.jocn.2017.02.001. Epub 2017 Mar 13.
Subarachnoid hemorrhage (SAH) is an important cause of stroke mortality and morbidity, especially in the young stroke population. Recent evidences indicate that neuroinflammation plays a critical role in both early brain injury and the delayed brain deterioration after SAH, including cellular and molecular components. Cerebral vasospasm (CV) can lead to death after SAH and independently correlated with poor outcome. Neuroinflammation is evidenced to contribute to the etiology of vasospasm. Besides, systemic inflammatory response syndrome (SIRS) commonly occurs in the SAH patients, with the presence of non-infectious fever and systematic complications. In this review, we summarize the evidences that indicate the prominent role of inflammation in the pathophysiology of SAH. That may provide the potential implications on diagnostic and therapeutic strategies.
蛛网膜下腔出血（SAH）是导致中风死亡和发病的重要原因，尤其是在年轻的中风患者群体中。最近的证据表明，神经炎症在SAH后的早期脑损伤和迟发性脑功能恶化中都起着关键作用，包括细胞和分子成分。脑血管痉挛（CV）可导致SAH后死亡，并与不良预后独立相关。有证据表明神经炎症促成了血管痉挛的病因。此外，全身炎症反应综合征（SIRS）在SAH患者中普遍存在，伴有非感染性发热和系统性并发症。在本综述中，我们总结了表明炎症在SAH病理生理学中突出作用的证据。这可能为诊断和治疗策略提供潜在的启示。
