细胞内钙释放通道：最新进展
Intracellular calcium release channels: an update.
作者信息
Santulli Gaetano, Nakashima Ryutaro, Yuan Qi, Marks Andrew R
机构信息
The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
出版信息
J Physiol. 2017 May 15;595(10):3041-3051. doi: 10.1113/JP272781.
Abstract
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP Rs) are calcium (Ca ) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.
摘要
兰尼碱受体（RyRs）和肌醇1,4,5-三磷酸受体（IPRs）是内质网/肌浆网（ER/SR）上的钙（Ca）释放通道。在此，我们总结该领域的最新进展，描述细胞内钙释放通道在调节线粒体健康和内皮功能方面最近发现的机制作用，为心力衰竭、高血压和糖尿病的治疗提供新的治疗选择。
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