兴奋-收缩偶联的生理学与病理生理学：兰尼碱受体的功能作用
Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor.
作者信息
Santulli Gaetano, Lewis Daniel R, Marks Andrew R
机构信息
The Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, Columbia University, New York, NY, USA.
出版信息
J Muscle Res Cell Motil. 2017 Feb;38(1):37-45. doi: 10.1007/s10974-017-9470-z. Epub 2017 Jun 26.
Abstract
Calcium (Ca) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E-C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
摘要
细胞内钙库释放钙在骨骼肌收缩调节中起关键作用。1型兰尼碱受体（RyR1）是骨骼肌肌细胞肌浆网（SR）上主要的钙释放通道，是兴奋-收缩（E-C）偶联所必需的。本文探讨了RyR1在骨骼肌生理和病理生理中的作用。
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本文引用的文献
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J Physiol. 2017 May 15;595(10):3041-3051. doi: 10.1113/JP272781.
2
Review of RyR1 pathway and associated pathomechanisms.
Acta Neuropathol Commun. 2016 Nov 17;4(1):121. doi: 10.1186/s40478-016-0392-6.
3
Structural Basis for Gating and Activation of RyR1.
Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075.
4
Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation.
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9069-74. doi: 10.1073/pnas.1609707113. Epub 2016 Jul 25.
5
Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS.
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8532-7. doi: 10.1073/pnas.1608859113. Epub 2016 Jul 8.
6
Ultrastructural Analysis of Self-Associated RyR2s.
Biophys J. 2016 Jun 21;110(12):2651-2662. doi: 10.1016/j.bpj.2016.05.013.
7
Adrenergic signaling in heart failure and cardiovascular aging.
Maturitas. 2016 Nov;93:65-72. doi: 10.1016/j.maturitas.2016.03.022. Epub 2016 Mar 26.
8
Mitochondrial calcium overload is a key determinant in heart failure.
Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11389-94. doi: 10.1073/pnas.1513047112. Epub 2015 Jul 27.
9
Mitochondrial oxidative stress promotes atrial fibrillation.
Sci Rep. 2015 Jul 14;5:11427. doi: 10.1038/srep11427.
10
Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.
Curr Mol Pharmacol. 2015;8(2):206-22. doi: 10.2174/1874467208666150507105105.
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