Stewart H J, McCann S H, Barker P J, Lee K E, Lamming G E, Flint A P
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
J Endocrinol. 1987 Nov;115(2):R13-5. doi: 10.1677/joe.0.115r013.
Sequencing of the 40 N-terminal amino acids of the blastocyst protein responsible for blocking corpus luteum regression in early pregnancy in sheep revealed a 37% homology with human alpha-interferon; 28% of the remaining amino acid changes were conservative. 125I-Labelled human alpha-interferon bound to membrane receptors from sheep uteri with an approximate Kd of 4 x 10(-11) M; binding was inhibited by unlabelled alpha-interferon or purified blastocyst antiluteolytic protein. The blastocyst antiluteolytic protein therefore closely resembles the interferon-alpha family of antiviral proteins.
对绵羊妊娠早期负责阻止黄体退化的囊胚蛋白的40个N端氨基酸进行测序，结果显示与人类α-干扰素具有37%的同源性；其余氨基酸变化中有28%是保守的。125I标记的人类α-干扰素与绵羊子宫的膜受体结合，其近似解离常数Kd为4×10(-11) M；未标记的α-干扰素或纯化的囊胚抗黄体溶解蛋白可抑制这种结合。因此，囊胚抗黄体溶解蛋白与抗病毒蛋白α-干扰素家族极为相似。
