Menkes D B, Aghajanian G K
Eur J Pharmacol. 1981 Aug 27;74(1):27-35. doi: 10.1016/0014-2999(81)90319-8.
Responses of single dorsal lateral geniculate neurons to iontophoretic noradrenaline, serotonin, and carbachol were studied following acute or chronic administration of tricyclic antidepressants. Long-term (15-20 day) treatment of rats with a variety of clinically effective tricyclics, including the atypical iprindole, significantly enhanced alpha 1-adrenoceptor mediated activations induced by noradrenaline. This change appears to require chronic treatment, since acute and short term (6-8 day) tricyclic regimens fail to consistently affect noradrenaline's action. Long term antidepressant treatment was also effective in enhancing geniculate neuron sensitivity to serotonin, in accord with previous studies, but failed to modify responses to the cholinergic agonist carbachol. It is suggested that the modulation of noradrenaline and serotonin receptor activity may represent a slowly developing action of tricyclic antidepressants which correlates with their delayed clinical effects.
在急性或慢性给予三环类抗抑郁药后，研究了单个背外侧膝状神经元对离子导入去甲肾上腺素、5-羟色胺和卡巴胆碱的反应。用包括非典型的茚满二酮在内的多种临床有效的三环类药物对大鼠进行长期（15 - 20天）治疗，可显著增强由去甲肾上腺素诱导的α1 - 肾上腺素能受体介导的激活作用。这种变化似乎需要长期治疗，因为急性和短期（6 - 8天）的三环类药物治疗方案未能持续影响去甲肾上腺素的作用。与先前的研究一致，长期抗抑郁治疗在增强膝状神经元对5-羟色胺的敏感性方面也有效，但未能改变对胆碱能激动剂卡巴胆碱的反应。有人提出，去甲肾上腺素和5-羟色胺受体活性的调节可能代表了三环类抗抑郁药的一种缓慢发展的作用，这与其延迟的临床效果相关。
