Farah Raymond, Samra Nava
Department of Internal Medicine B, Ziv Medical Center, Safed, Israel.
Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
J Clin Lab Anal. 2018 Jan;32(1). doi: 10.1002/jcla.22189. Epub 2017 Mar 17.
Mean platelets volume (MPV) is a marker, which indicates platelet function, and is a potential link between inflammation and thrombosis. Previous studies have found a relation between high MPV levels and high risk of stroke. Another factor that has been associated with the risk of stroke is neutrophil to lymphocyte ratio (NLR). Several studies have reported an association between increased NLR and increased risk of cerebrovascular disease. It was found that NLR levels have a relation to the prognosis as well. Since both NLR and MPV have been associated with increased risk of cardiovascular disease, together they may predict the risk of stroke and the prognosis with higher sensitivity and specificity.
This is a descriptive retrospective study. Data were gathered from medical records of patients who applied the Ziv medical center and were diagnosed with stroke. Stroke severity was evaluated using the NIHSS (national institutes of health stroke scale). MPV and NLR levels of patients with stroke were compared to those of 30 healthy individuals.
Neutrophil to lymphocyte ratio levels were found significantly higher in patients with stroke compared with healthy individuals. NLR was also found higher in patients with moderate/severe stroke compared with those with minor stroke. No association was found between MPV level, the risk of stroke, and stroke prognosis. Moreover, an interaction effect between MPV and NLR level was not found.
Neutrophil to lymphocyte ratio is a good predictive factor of stroke and stroke prognosis. Further prospective studies are needed to establish the relationship between the MPV level and the risk of stroke. NLR and MPV interaction effect can be tested again in the future after establishing the association between MPV, the risk of stroke, and stroke prognosis.
平均血小板体积（MPV）是一种指示血小板功能的标志物，是炎症与血栓形成之间的潜在联系。先前的研究发现MPV水平升高与中风高风险之间存在关联。另一个与中风风险相关的因素是中性粒细胞与淋巴细胞比值（NLR）。多项研究报告了NLR升高与脑血管疾病风险增加之间的关联。还发现NLR水平与预后也有关系。由于NLR和MPV均与心血管疾病风险增加有关，它们可能共同以更高的敏感性和特异性预测中风风险及预后。
这是一项描述性回顾性研究。数据收集自就诊于齐夫医疗中心并被诊断为中风的患者的病历。使用美国国立卫生研究院卒中量表（NIHSS）评估中风严重程度。将中风患者的MPV和NLR水平与30名健康个体的水平进行比较。
与健康个体相比，中风患者的中性粒细胞与淋巴细胞比值水平显著更高。与轻度中风患者相比，中度/重度中风患者的NLR也更高。未发现MPV水平、中风风险和中风预后之间存在关联。此外，未发现MPV和NLR水平之间存在交互作用。
中性粒细胞与淋巴细胞比值是中风及中风预后的良好预测因素。需要进一步的前瞻性研究来确定MPV水平与中风风险之间的关系。在确定MPV、中风风险和中风预后之间的关联后，未来可再次测试NLR和MPV的交互作用。
