Şahin A, Yetişgin A, Şahin M, Durmaz Y, Cengiz A K
Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey. E-mail:
Division of Physical Therapy and Medicine, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.
West Indian Med J. 2015 May 6;65(1):165-169. doi: 10.7727/wimj.2014.202.
In humans, it has been suggested that low-level mean platelet volume (MPV) may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body.
To evaluate the association of MPV with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease Activity Score-28 (DAS-28), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with rheumatic diseases.
The study consisted of 261 patients with rheumatoid arthritis (203 females, 77.8%; 58 males, 22.2%), 85 patients with ankylosing spondylitis (57 males, 67.1%; 28 females, 32.9%), 56 patients with familial Mediterranean fever (32 females, 57.1%; 24 males, 42.9%) and 194 patients (139 females, 71.6%; 55 males, 28.4%) with other rheumatic diseases (Behçet's disease, psoriatic arthritis, spondyloarthropathy, systemic lupus erythematosus, systemic sclerosis, or undifferentiated connective tissue disease).
There was an inversely significant correlation between MPV and ESR and CRP in patients with rheumatoid arthritis (r = -0.164, p = 0.008). Mean platelet volume was negatively correlated with DAS-28-ESR/CRP (r = -0.393, p < 0.001) in rheumatoid arthritis. Mean platelet volume was inversely correlated with BASDAI (r = -0.580, p < 0.001) in ankylosing spondylitis. In the group with familial Mediterranean fever (especially M694V homozygous), there was a negative correlation between MPV and ESR and CRP (p < 0.001). Mean platelet volume and CRP were negatively correlated in psoriatic arthritis (r = -0.599, p = 0.011). Mean platelet volume and ESR were inversely related in patients with systemic lupus erythematosus (r = -0.421, p = 0.045). There was a negative correlation between MPV and ESR (r = -0.219, p = 0.002), and between MPV and CRP (r = -0.208, p = 0.004) in other rheumatic diseases.
The lower MPV level surrogates active and/or chronic inflammatory state in the body. Thus, MPV may be used as a negative acute-phase reactant in rheumatic diseases.
在人类中，有研究表明低水平的平均血小板体积（MPV）可能与炎症引起的继发性血栓形成有关。因此，MPV可作为体内炎症的一个指标。
评估风湿性疾病患者中MPV与红细胞沉降率（ESR）、C反应蛋白（CRP）、疾病活动评分-28（DAS-28）以及巴斯强直性脊柱炎疾病活动指数（BASDAI）之间的关联。
该研究纳入了261例类风湿关节炎患者（203例女性，占77.8%；58例男性，占22.2%）、85例强直性脊柱炎患者（57例男性，占67.1%；28例女性，占32.9%）、56例家族性地中海热患者（32例女性，占57.1%；24例男性，占42.9%）以及194例其他风湿性疾病患者（139例女性，占71.6%；55例男性，占28.4%）（白塞病、银屑病关节炎、脊柱关节炎、系统性红斑狼疮、系统性硬化症或未分化结缔组织病）。
类风湿关节炎患者中，MPV与ESR和CRP之间存在显著负相关（r = -0.164，p = 0.008）。类风湿关节炎患者中，平均血小板体积与DAS-28-ESR/CRP呈负相关（r = -0.393，p < 0.001）。强直性脊柱炎患者中，平均血小板体积与BASDAI呈负相关（r = -0.580，p < 0.001）。在家族性地中海热组（尤其是M694V纯合子）中，MPV与ESR和CRP之间存在负相关（p < 0.001）。银屑病关节炎患者中，平均血小板体积与CRP呈负相关（r = -0.599，p = 0.011）。系统性红斑狼疮患者中，平均血小板体积与ESR呈负相关（r = -0.421，p = 0.045）。其他风湿性疾病患者中，MPV与ESR之间存在负相关（r = -0.219，p = 0.002），与CRP之间也存在负相关（r = -0.208，p = 0.004）。
较低的MPV水平代表体内活跃和/或慢性炎症状态。因此，MPV可作为风湿性疾病中的一种负急性期反应物。
