Wieschaus Eric, Marsh J L, Gehring Walter
Zoological Institute, University of Zürich, Künstlergasse 16, CH-8006, Zürich, Switzerland.
Department of Biology, University of Virginia, 22901, Charlottesville, Virginia, USA.
Wilehm Roux Arch Dev Biol. 1978 Mar;184(1):75-82. doi: 10.1007/BF00848670.
Females homozygous for a newly isolated mutation induced by ethyl methane sulphonate,fs(1)K10, lay abnormally shaped eggs in which the dorsal appendages of the chorion are enlarged and fused ventrally. The eggs are usually not fertilized and development is never normal beyond the blastoderm stage. The mutant was mapped to the tip of the X-chromosome with a meiotic position of 1-0.5 and a cytological location between 2B17 and 3A3. Using germ line mosaics constructed by transplantation of pole cells, it was shown that the abnormal morphology and the sterility are obtained only when the germ line is homozygous for the mutant.
对于一个新分离出的由甲磺酸乙酯诱导产生的突变（fs(1)K10）纯合的雌性果蝇，会产下形状异常的卵，其中卵壳的背侧附属物增大并在腹侧融合。这些卵通常无法受精，并且在囊胚期之后发育也从未正常过。该突变体被定位到X染色体的末端，减数分裂位置为1-0.5，细胞学位置在2B17和3A3之间。通过移植极细胞构建生殖系嵌合体，结果表明只有当生殖系为突变体纯合时，才会出现异常形态和不育现象。
