Hartenstein Volker, Campos-Ortega Jose A
Institut für Entwicklungsphysiologie der Universität zu Köln, Gyrhofstraße 17, D-5000, Köln 41, Federal Republic of Germany.
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):308-325. doi: 10.1007/BF00848159.
This paper deals with morphological aspects of early neurogenesis inDrosophila, in particular with the segregation of neuroblasts from the neurogenic region of the ectoderm and the pattern formed by those wells within both the germ band and the procephalic lobe. The neurogenic ectoderm was found to contain neural precursors intermingled with epidermal precursors, extending from the midline up to the primordia of the tracheal tree along the germ band and laterodorsally in the procephalic lobe. Germ band neuroblasts segregate from the neurogenic ectoderm during a period of several hours according to characteristic spatial and temporal patterns. During the first half of the segregation process the pattern of germ band neuroblasts was found to be the same in different animals in both spatial arrangement and number of cells; this permitted the identification of individual neuroblasts from different embryos. Later in development several difficulties were encountered which precluded an exact description of the neuroblast pattern. The constitution of the neurogenic region is discussed in relation to the phenotype of mutants affecting neurogenesis.
本文探讨了果蝇早期神经发生的形态学方面，特别是神经母细胞从外胚层神经源区域的分离以及在胚带和前脑叶中这些细胞所形成的模式。研究发现，神经源外胚层包含与表皮前体细胞混合的神经前体细胞，其沿着胚带从中线延伸至气管树原基，并在前脑叶的背外侧分布。胚带神经母细胞在数小时内根据特定的时空模式从神经源外胚层分离出来。在分离过程的前半段，发现不同动物中胚带神经母细胞的模式在空间排列和细胞数量上是相同的；这使得能够从不同胚胎中识别出单个神经母细胞。在发育后期遇到了一些困难，妨碍了对神经母细胞模式的精确描述。本文还结合影响神经发生的突变体表型讨论了神经源区域的组成。
