Pietsch Paul
Department of Visual Sciences, School of Optometry and the Medical Sciences Program, School of Medicine, Indiana University, 47405, Bloomington, Indiana, USA.
Rouxs Arch Dev Biol. 1987 Mar;196(3):169-175. doi: 10.1007/BF00376311.
Regenerating tails and limbs of axolotl larvae (A. mexicanum) were studied for overall growth and for mitosis after the animals received intraperitoneal injections of all-trans retinoic acid. Both processes were depressed to approximately the same extent (60-70%). Some mitosis always survived, even when the treatment was in effect during the entire history of the regenerate. The treatment duration was a major variable in the severity of the effect, whereas the post-amputation age of the regenerate was not. In limb regenerates the epithelial cap and the mesenchymal blastema were affected to roughly the same degree.
研究了墨西哥钝口螈幼体（墨西哥钝口螈）再生的尾巴和四肢在接受全反式视黄酸腹腔注射后的整体生长和有丝分裂情况。这两个过程均受到约60%-70%程度的抑制。即便在整个再生过程中都进行治疗，仍总有一些有丝分裂得以存活。治疗持续时间是影响效应严重程度的主要变量，而再生部位截肢后的年龄则不是。在肢体再生中，上皮帽和间充质芽基受到的影响大致相同。
