• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acid.

作者信息

Roberts A B, Roche N S, Sporn M B

出版信息

Nature. 1985;315(6016):237-9. doi: 10.1038/315237a0.

DOI:10.1038/315237a0
PMID:2987698
Abstract

Fischer rat 3T3 (FR3T3) fibroblasts transfected with a cellular myc gene can be induced to grow and form colonies in soft agar by treatment either with epidermal growth factor (EGF) alone or with the combination of platelet-derived growth factor (PDGF) and type-beta transforming growth factor (TGF-beta). We now show that induction of anchorage-independent growth by each of these sets of growth factors involves different cellular pathways which can be distinguished by their sensitivity to retinoic acid. Colony formation induced by the combined action of PDGF and TGF-beta is 100-fold more sensitive to inhibition by retinoic acid than is colony formation induced by treatment of the myc-transfected cells with EGF. Moreover, retinoic acid (10(-8) M) is inhibitory for colony growth whenever TGF-beta is present, regardless of whether the effects of TGF-beta are stimulatory, as occurs in the presence of PDGF, or inhibitory, as found in the presence of EGF.

摘要

相似文献

1
Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acid.
Nature. 1985;315(6016):237-9. doi: 10.1038/315237a0.
2
Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.myc和ras转染细胞对生长因子的不同反应：表皮生长因子对myc转染细胞的选择性刺激
Mol Cell Biol. 1986 Mar;6(3):870-7. doi: 10.1128/mcb.6.3.870-877.1986.
3
Type beta transforming growth factor: a bifunctional regulator of cellular growth.β型转化生长因子：细胞生长的双功能调节因子。
Proc Natl Acad Sci U S A. 1985 Jan;82(1):119-23. doi: 10.1073/pnas.82.1.119.
4
Transforming growth factor-beta and retinoic acid modulate phenotypic transformation of normal rat kidney cells induced by epidermal growth factor and platelet-derived growth factor.转化生长因子-β和视黄酸调节表皮生长因子和血小板衍生生长因子诱导的正常大鼠肾细胞的表型转化。
J Biol Chem. 1986 Apr 15;261(11):5003-9.
5
Antagonistic actions of retinoic acid and dexamethasone on anchorage-independent growth and epidermal growth factor binding of normal rat kidney cells.视黄酸和地塞米松对正常大鼠肾细胞非贴壁依赖性生长及表皮生长因子结合的拮抗作用。
Cancer Res. 1984 Apr;44(4):1635-41.
6
Altered response to growth factors or retinoic acid in phenotypic transformation of normal rat kidney cells expressing human c-fos gene.在表达人c-fos基因的正常大鼠肾细胞表型转化过程中对生长因子或视黄酸的反应改变。
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1273-80. doi: 10.1016/0006-291x(91)92076-v.
7
Suppression of carcinogenesis by retinoids: interactions with peptide growth factors and their receptors as a key mechanism.
Princess Takamatsu Symp. 1985;16:149-58.
8
Platelet-derived growth factor or basic fibroblast growth factor induce anchorage-independent growth of human fibroblasts.血小板衍生生长因子或碱性成纤维细胞生长因子可诱导人成纤维细胞的非贴壁依赖性生长。
J Cell Physiol. 1988 Dec;137(3):588-92. doi: 10.1002/jcp.1041370328.
9
Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.转化生长因子和非转化生长因子存在于胎鼠颅骨条件培养液中。
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7335-9. doi: 10.1073/pnas.82.21.7335.
10
Effects of epidermal growth factor and transforming growth factor-beta 1 on rat heart endothelial cell anchorage-dependent and -independent growth.表皮生长因子和转化生长因子-β1 对大鼠心脏内皮细胞贴壁依赖性和非贴壁依赖性生长的影响。
Exp Cell Res. 1990 Jan;186(1):122-9. doi: 10.1016/0014-4827(90)90218-y.

引用本文的文献

1
Vitamin D and Retinoic Acid Require Protein Kinase C Activity and Reactive Oxygen Species as Opposing Signals Regulating / Expression in Caco-2 and T84 Colon Carcinoma Cells.维生素D和视黄酸需要蛋白激酶C活性和活性氧作为调节Caco-2和T84结肠癌细胞中/表达的相反信号。
Biomolecules. 2025 May 13;15(5):711. doi: 10.3390/biom15050711.
2
Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010.两名患者来源的导管原位癌（DCIS）细胞系 ETCC-006 和 ETCC-010 的分子和细胞特征。
BMC Cancer. 2021 Jul 8;21(1):790. doi: 10.1186/s12885-021-08511-2.
3
The effects of retinoic acid on mitosis during tail and limb regeneration in the axolotl larva, Ambystoma mexicanum.
视黄酸对墨西哥钝口螈幼体尾巴和肢体再生过程中细胞有丝分裂的影响。
Rouxs Arch Dev Biol. 1987 Mar;196(3):169-175. doi: 10.1007/BF00376311.
4
Tissue engineered strategies for skeletal muscle injury.组织工程化策略治疗骨骼肌损伤。
Stem Cells Int. 2012;2012:175038. doi: 10.1155/2012/175038. Epub 2011 Nov 10.
5
Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene.在外源c-myc基因转移后，C3H/10T1/2细胞中辐射诱导的转化增加。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4131-4. doi: 10.1073/pnas.84.12.4131.
6
Effects of type beta transforming growth factor in combination with retinoic acid or tumor necrosis factor on proliferation of a human glioblastoma cell line and clonogenic cells from freshly resected human brain tumors.β型转化生长因子联合视黄酸或肿瘤坏死因子对人胶质母细胞瘤细胞系及新鲜切除的人脑肿瘤克隆形成细胞增殖的影响。
Cancer Immunol Immunother. 1988;26(3):273-9. doi: 10.1007/BF00199941.
7
Differential response to retinoic acid of Syrian hamster embryo fibroblasts expressing v-src or v-Ha-ras oncogenes.表达v-src或v-Ha-ras癌基因的叙利亚仓鼠胚胎成纤维细胞对维甲酸的不同反应。
Mol Cell Biol. 1986 Oct;6(10):3341-8. doi: 10.1128/mcb.6.10.3341-3348.1986.
8
Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.myc和ras转染细胞对生长因子的不同反应：表皮生长因子对myc转染细胞的选择性刺激
Mol Cell Biol. 1986 Mar;6(3):870-7. doi: 10.1128/mcb.6.3.870-877.1986.
9
Distribution and modulation of the cellular receptor for transforming growth factor-beta.转化生长因子-β细胞受体的分布与调节
J Cell Biol. 1987 Aug;105(2):965-75. doi: 10.1083/jcb.105.2.965.
10
Effect of retinoids on growth factor-induced anchorage independent growth of human fibroblasts.维甲酸对生长因子诱导的人成纤维细胞锚定非依赖性生长的影响。
In Vitro Cell Dev Biol. 1989 Nov;25(11):1009-15. doi: 10.1007/BF02624134.