Santamaria Pedro, Deatrick Janet, Randsholt Neel B
Centre de Génétique Moléculaire du C.N.R.S., F-91198, Gif-sur-Yvette Cedex, France.
Laboratoire propre du C.N.R.S., associe à l'Université Pierre et Marie Curie, Paris VI, France.
Rouxs Arch Dev Biol. 1989 Jun;198(2):65-77. doi: 10.1007/BF02447741.
The effects ofpolyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous forph, sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the wing has special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8-16 cells affect the polarity of the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellular communication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerative growth, and reorganize into a new pattern. The pleiotropic phenotypes ofph mutants are explained according to a common hypothesis aboutph function.
在一项克隆分析中研究了多同源异型（ph）突变体在成虫盘细胞中的作用。纯合ph的细胞克隆在几次分裂后会分离出来，这可能是细胞亲和力改变的结果。翅膀的背腹边缘具有特殊特征，可延缓这种现象。8 - 16个细胞的克隆的形成和排除会影响野生型相邻细胞的极性，并可引发图案重复。结果表明，细胞间通讯缺陷会阻止野生型细胞维持协调的位置信息。细胞通过再生生长做出反应，并重新组织成新的图案。根据关于ph功能的一个共同假说来解释ph突变体的多效性表型。
