非霍奇金淋巴瘤患者外周血单个核细胞中EB病毒DNA的临床意义
The clinical significance of Epstein-Barr virus DNA in peripheral blood mononuclear cells in patients with non-Hodgkin lymphoma.
作者信息
Chen Yi, Zheng Xiaoyun, Chen Buyuan, Yang Xiaozhu, Zheng Jing, Zheng Zhihong, Yang Ting, Liu Tingbo, Hu Jianda
机构信息
a Fujian Provincial Key Laboratory on Hematology , Fujian Medical University Union Hospital, Fujian Institute of Hematology , Fuzhou , Fujian , China.
出版信息
Leuk Lymphoma. 2017 Oct;58(10):2349-2355. doi: 10.1080/10428194.2017.1300894. Epub 2017 Mar 17.
The aim of the study was to determine the clinical significance of EBV DNA in the peripheral blood mononuclear cells (PBMCs) from the patients with non-Hodgkin lymphoma (NHL). Newly diagnosed patients with NHL were enrolled in the study (n = 328), and clinical data retrospectively analyzed. EBV DNA was detectable in 34.8% of patients, and the positivity rate was 51.6% for T/NK cell subtype and 24.3% for B cell subtype (p < .001). In diffuse large B cell lymphoma (DLBCL), extranodal NK/T-cell lymphoma, nasal type (ENKTL), peripheral T-cell lymphoma not otherwise classified (PTCL.NOS), or angioimmunoblastic T cell lymphoma (AITL), positive EBV DNA before treatment was associated with more risk factors with prognostic significance, including older age, advanced stage, extranodal involvement, bone marrow infiltration, elevated LDH, and B symptoms, and with poor prognosis.
该研究的目的是确定非霍奇金淋巴瘤（NHL）患者外周血单个核细胞（PBMC）中EBV DNA的临床意义。新诊断的NHL患者被纳入研究（n = 328），并对临床数据进行回顾性分析。34.8%的患者可检测到EBV DNA，T/NK细胞亚型的阳性率为51.6%，B细胞亚型为24.3%（p < 0.001）。在弥漫性大B细胞淋巴瘤（DLBCL）、结外NK/T细胞淋巴瘤，鼻型（ENKTL）、外周T细胞淋巴瘤，非特指型（PTCL.NOS）或血管免疫母细胞性T细胞淋巴瘤（AITL）中，治疗前EBV DNA阳性与更多具有预后意义的危险因素相关，包括年龄较大、晚期、结外受累、骨髓浸润、乳酸脱氢酶升高和B症状，且预后较差。
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