Arisaka Osamu, Sairenchi Toshimi, Ichikawa Go, Koyama Satomi
Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi-ken, 321-0293.
Department of Public Health, Dokkyo Medical University School of Medicine, Mibu.
J Pediatr Endocrinol Metab. 2017 Apr 1;30(4):455-457. doi: 10.1515/jpem-2016-0227.
To elucidate the effect of early growth patterns on the metabolic sensitivity to adiposity, we examined the relationship between the homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) levels at 12 years of age in 101 boys and 91 girls in a birth cohort. Children with an increase in BMI from the ages of 1.5 to 3 years exhibited a greater increase of HOMA-IR per BMI increase at 12 years of age compared to those with a decrease in BMI or stable BMI from 1.5 to 3 years. This suggests that children who show an increase in BMI from 1.5 to 3 years, a period normally characterized by a decreased or stable BMI, are more prone to developing insulin resistance at 12 years of age.
为阐明早期生长模式对肥胖代谢敏感性的影响，我们在一个出生队列中，对101名男孩和91名女孩12岁时的胰岛素抵抗稳态模型评估（HOMA-IR）与体重指数（BMI）水平之间的关系进行了研究。与1.5至3岁时BMI下降或稳定的儿童相比，1.5至3岁时BMI增加的儿童在12岁时每增加一个BMI单位，HOMA-IR的增幅更大。这表明，在通常以BMI下降或稳定为特征的1.5至3岁期间BMI增加的儿童，在12岁时更容易发生胰岛素抵抗。
