Garn S M, Burdi A R, Babler W J, Asp R
J Dent Res. 1979 Feb;58(2):554-9. doi: 10.1177/00220345790580020301.
As shown in composite reconstructions made from optically-projected measurements of 10mu frontal maxillofacial sections of 20 histologically normal fetuses and embryos in the 70-255 mm CRL range, individual differences in relative tooth size and interdental spacing are evident by 10.5-11 weeks of gestation, and age-corrected crown-size correlations (r=0.40) approximate those in postnatal life. Despite an eight-fold increase in crown dimensions, interdental spacing remains approximately constant after 150 mm CRL, suggesting that the tooth organs or the periodontal membranes are able to maintain spacing, into the third trimester.
从对20例组织学正常、头臀长在70 - 255毫米范围内的胎儿和胚胎的10微米额部颌面切片进行光学投影测量所做的复合重建中可以看出，妊娠10.5 - 11周时，相对牙齿大小和牙间隙的个体差异就很明显，且年龄校正后的牙冠大小相关性（r = 0.40）与出生后相似。尽管牙冠尺寸增加了八倍，但在头臀长达到150毫米后，牙间隙仍大致保持不变，这表明牙齿器官或牙周膜能够在孕晚期维持间隙。
