Mittal K R, True L D
Department of Pathology, Bellevue Hospital, New York, NY 10016.
Arch Pathol Lab Med. 1988 Mar;112(3):302-3.
Eight cases of granular cell tumor were stained with Luxol fast blue to look for the presence of myelin. Luxol fast blue-positive granules were present in all cases. One case was studied ultrastructurally. It showed evidence of origin of granules as infoldings of cell membrane by a process similar to myelin formation around axons. These infoldings subsequently appear to be phagocytosed by lysosomes, resulting in the typical granules of the granular cell tumor.
