Formiggini G, Sassi S, Bovina C, Marchetti M
Dipartimento di Biochimica, Università di Bologna, Italy.
Int J Vitam Nutr Res. 1987;57(4):405-9.
The effect of acute phenobarbitone treatment on the distribution of endogenous bound folates in three specific cytosolic folate-binding proteins (FBP-C), has been studied in rat liver. The bound folate amount shows no difference between treated and control rats. As it is well known that FBP's preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP's in these animals.
在大鼠肝脏中研究了急性苯巴比妥处理对三种特定胞质叶酸结合蛋白（FBP-C）中内源性结合叶酸分布的影响。处理组大鼠和对照组大鼠之间的结合叶酸量没有差异。众所周知，FBP优先结合较长链的多聚谷氨酸，而在苯巴比妥处理的大鼠肝脏中其含量明显较低，这可能表明较短链的叶酸在这些动物中也能与FBP结合。
