Formiggini G, Sassi S, Bovina C, Marchetti M
Int J Vitam Nutr Res. 1987;57(1):59-63.
The effect of castration and testosterone treatment on the distribution of [3H] radioactive and endogenous bound folates in hepatic cytosolic folate binding proteins (FBP-C) has been studied in rats. The distribution of [3H] radioactive bound folates in these FBP's shows no significant difference in the three experimental group animals. On the contrary a significant decrease in the amount of endogenous bound folates is observed in castrated if compared with control rats, particularly marked for FBP-CI and FBP-CII bound folates. The testosterone treatment of castrated rats partially restores bound folate levels. The decrease of bound folates in castrated rats might be ascribable to a lower availability of longer-chain forms, almost the ones that bind to FBP's; however lower binding protein content and/or lower affinity for ligands cannot be excluded.
在大鼠中研究了去势和睾酮治疗对肝细胞质叶酸结合蛋白（FBP-C）中[3H]放射性和内源性结合叶酸分布的影响。在这三个实验组动物中，这些FBP中[3H]放射性结合叶酸的分布没有显著差异。相反，与对照大鼠相比，去势大鼠中内源性结合叶酸的量显著减少，特别是FBP-CI和FBP-CII结合的叶酸尤为明显。对去势大鼠进行睾酮治疗可部分恢复结合叶酸水平。去势大鼠中结合叶酸的减少可能归因于长链形式（几乎是与FBP结合的那些）的可用性较低；然而，不能排除结合蛋白含量较低和/或对配体的亲和力较低的情况。
