Crow T J
Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, U.K.
J Psychiatr Res. 1987;21(4):479-85. doi: 10.1016/0022-3956(87)90096-3.
According to the retrovirus-transposon hypothesis, psychosis is due to the expression of a pathogenic sequence (a "virogene") integrated in the genome and either inherited from an affected or predisposed parent or acquired in the course of reproduction by a genetic rearrangement (e.g. a transposition or the generation of a tandem repeat). The psychoses are viewed as a continuum extending from unipolar through bipolar and schizo-affective disorder to schizophrenia with increasing severity of defect, movement along this continuum occurring by such genetic rearrangements. The locus at which these changes take place is envisaged as related to the genetic determinants of cerebral lateralisation (the "cerebral dominance gene") the interaction between potential pathogen and growth factor gene having possible growth enhancing effects. Such beneficial effects may have ensured the survival of this "hot-spot" in the genome.
根据逆转录病毒转座子假说，精神病是由于整合在基因组中的致病序列（“病毒基因”）的表达所致，该序列要么从受影响或易患疾病的父母那里遗传而来，要么在生殖过程中通过基因重排（例如转座或串联重复序列的产生）获得。精神病被视为一个连续体，从单相障碍延伸至双相障碍、分裂情感性障碍，再到精神分裂症，缺陷严重程度不断增加，沿着这个连续体的变化是由这种基因重排引起的。这些变化发生的位点被设想与大脑偏侧化的遗传决定因素（“大脑优势基因”）有关，潜在病原体与生长因子基因之间的相互作用可能具有促进生长的作用。这种有益作用可能确保了基因组中这个“热点”的存活。
