小鼠鸟氨酸转氨甲酰酶的遗传结构。
The genetic structure of mouse ornithine transcarbamylase.
作者信息
Scherer S E, Veres G, Caskey C T
机构信息
Institute for Molecular Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.
出版信息
Nucleic Acids Res. 1988 Feb 25;16(4):1593-601. doi: 10.1093/nar/16.4.1593.
Abstract
The gene encoding the mouse urea cycle enzyme, ornithine transcarbamylase has been isolated on five partially overlapping bacteriophage lambda clones. We have characterized the gene and found that it is split between ten exons distributed over approximately 70 kb of the X chromosome. The introns range in size from 88 bases to the relatively unusual size of approximately 26 kilobases, while the splice donor/splice acceptor sequences conform to the consensus established for other eukaryotic genes.
摘要
编码小鼠尿素循环酶鸟氨酸转氨甲酰酶的基因已在五个部分重叠的λ噬菌体克隆中分离出来。我们对该基因进行了表征，发现它被分布在X染色体约70 kb区域的十个外显子分隔开。内含子大小从88个碱基到约26千碱基这种相对不寻常的大小不等，而剪接供体/剪接受体序列符合为其他真核基因确立的共有序列。
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