Guclu Hande, Ozal Sadık A, Pelitli Gurlu Vuslat, Özgün Gülben Sayılan, Özgün Eray
1 Department of Ophthalmology, Trakya University, Faculty of Medicine, Edirne - Turkey.
2 Department of Biochemistry, Trakya University, Faculty of Medicine, Edirne - Turkey.
Eur J Ophthalmol. 2017 Nov 8;27(6):735-739. doi: 10.5301/ejo.5000942.
To demonstrate the relationship between ischemia and plasma fibrinogen and serum albumin levels in cases of retinal vein occlusion (RVO).
This study included 44 patients with central RVO (CRVO), 68 patients with branch RVO (BRVO), and 54 age- and sex-matched controls, for a total of 166 subjects. All of the subjects underwent full ophthalmologic examinations and complete physical examinations, including a detailed medical history and blood count, and biochemical parameters.
The mean fibrinogen to albumin ratios were 92.5 ± 36.1 for the patients with CRVO, 84.5 ± 31.5 for the patients with BRVO, and 68.4 ± 12.2 for the control group. Overall, the patients with CRVO and patients with BRVO with ischemia had higher fibrinogen to albumin ratios and higher fibrinogen levels. Moreover, significant positive correlations were found between ischemia and the fibrinogen to albumin ratio (r = 0.732, p = 0.001) and the fibrinogen level (r = 0.669, p = 0.001).
The fibrinogen to albumin ratio is significantly associated with ischemic RVO. Instead of complicated and invasive methods, such as a retinal angiogram, the fibrinogen to albumin ratio could be a useful initial diagnostic test to predict ischemia in RVO.
探讨视网膜静脉阻塞（RVO）患者缺血情况与血浆纤维蛋白原及血清白蛋白水平之间的关系。
本研究纳入44例中心性视网膜静脉阻塞（CRVO）患者、68例分支性视网膜静脉阻塞（BRVO）患者以及54例年龄和性别匹配的对照者，共166名受试者。所有受试者均接受了全面的眼科检查和完整的体格检查，包括详细的病史、血常规及生化指标检查。
CRVO患者的纤维蛋白原与白蛋白平均比值为92.5±36.1，BRVO患者为84.5±31.5，对照组为68.4±12.2。总体而言，CRVO患者及伴有缺血的BRVO患者的纤维蛋白原与白蛋白比值及纤维蛋白原水平更高。此外，缺血与纤维蛋白原与白蛋白比值（r = 0.732，p = 0.001）以及纤维蛋白原水平（r = 0.669，p = 0.001）之间存在显著正相关。
纤维蛋白原与白蛋白比值与缺血性RVO显著相关。相较于视网膜血管造影等复杂且有创的检查方法，纤维蛋白原与白蛋白比值可作为预测RVO缺血情况的一项有用的初步诊断检测指标。
