Department of Neurosurgery, West China Hospital, Sichuan University, Guoxue Street, Chengdu, China.
Medicine (Baltimore). 2021 Apr 30;100(17):e25764. doi: 10.1097/MD.0000000000025764.
Inflammation plays an important role in the pathophysiology of subarachnoid hemorrhage (SAH). Recent studies have indicated that the albumin to fibrinogen ratio (AFR) is a useful biomarker of inflammation.This research aimed to determine the ability of AFR to predict the prognosis of patients with SAH.A total of 440 patients with SAH who had been diagnosed within 72 hours of symptom onset were retrospectively reviewed. Clinical findings and laboratory data were retrieved from the hospital database. Functional outcome was measured according to the modified Rankin scale at 30 days. Logistic regression analysis was used to evaluate the correlation between AFR and the prognosis of patients with SAH. Receiver operating characteristic (ROC) analysis was performed to determine the prognostic ability of AFR at admission to predict the 30-day outcomes.The average age of all 440 patients with SAH was 56.75 ± 11.19 years and 31.4% (138) were male. Of these patients, 161 exhibited unfavorable outcomes at 30 days. According to the multivariate logistic regression analysis, the AFR was positively correlated with the outcome of patients with SAH (odds ratio 0.939, 95% confidence interval 0.885-0.996, P = .038). The ROC analysis revealed an area under the curve of 0.713 for AFR's ability to predict the 30-day outcomes.AFR is independently associated with the outcome of SAH patients. As a parameter that can be easily assessed at admission, AFR could be used to help the decision-making of clinical treatment.
炎症在蛛网膜下腔出血（SAH）的病理生理学中起着重要作用。最近的研究表明，白蛋白与纤维蛋白原比值（AFR）是炎症的有用生物标志物。本研究旨在确定 AFR 预测 SAH 患者预后的能力。回顾性分析了 440 例发病后 72 小时内确诊的 SAH 患者。从医院数据库中提取临床发现和实验室数据。根据改良 Rankin 量表在 30 天时测量功能结局。逻辑回归分析用于评估 AFR 与 SAH 患者预后之间的相关性。进行接收者操作特征（ROC）分析，以确定入院时 AFR 预测 30 天结局的预后能力。所有 440 例 SAH 患者的平均年龄为 56.75±11.19 岁，其中 31.4%（138 例）为男性。这些患者中，有 161 例在 30 天时预后不良。根据多变量逻辑回归分析，AFR 与 SAH 患者的预后呈正相关（优势比 0.939，95%置信区间 0.885-0.996，P=0.038）。ROC 分析显示 AFR 预测 30 天结局的曲线下面积为 0.713。AFR 与 SAH 患者的预后独立相关。作为入院时可轻易评估的参数，AFR 可用于帮助临床治疗的决策。
