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[近期人类免疫缺陷病毒感染病例中预后良好的吉兰-巴雷综合征]

[Guillain-Barré syndrome with favorable outcome in a case of recent human immunodeficiency virus infection].

作者信息

Persuy P, Arnott G, Fortier B, Ajana F, Blondel M, Fourrier F, Dewilde A, Maniez-Montreuil M

机构信息

Service de Neurologie B, CHU Lille.

出版信息

Rev Neurol (Paris). 1988;144(1):32-5.

PMID:2831607
Abstract

An acute polyradiculoneuropathy occurred in a 30 years homosexual male. E.L.I.S.A. test and Western Blot showed recent infection by H.I.V. Besides, endogenous reinfestation by cytomegalovirus was found: high concentrations of specific IgG antibodies and presence of the virus in the blood. T4 helper cells were severely reduced, without any other sign of cellular immunity failure. None of the two viruses was found in the nervous biopsy. This Guillain-Barre syndrome with a subsequent cellular reaction in the CSF, is probably to be related to an immunoallergic mechanism. Brief increase of antibodies specific for HBsAg and Borrelia Burgdorferri and the beneficial effect of plasmapheresis, supported this view. Two months later, the patient showed superficial lymph nodes hyperplasia, without any other symptom of pre-Acquired Immuno-Depression Syndrome.

摘要

一名30岁的同性恋男性发生了急性多发性神经根神经病。酶联免疫吸附测定(ELISA)试验和免疫印迹法显示近期感染了人类免疫缺陷病毒(HIV)。此外,还发现了巨细胞病毒的内源性再感染:血液中特异性IgG抗体浓度高且存在该病毒。T4辅助细胞严重减少,无任何其他细胞免疫功能衰竭迹象。在神经活检中未发现这两种病毒中的任何一种。这种伴有脑脊液中随后细胞反应的格林-巴利综合征可能与免疫过敏机制有关。乙肝表面抗原(HBsAg)和伯氏疏螺旋体特异性抗体的短暂增加以及血浆置换的有益效果支持了这一观点。两个月后,患者出现浅表淋巴结增生,无任何其他获得性免疫缺陷综合征前期症状。

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