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伴有外周神经巨细胞病毒感染的吉兰-巴雷综合征

Guillain-Barré syndrome with cytomegalovirus infection of peripheral nerves.

作者信息

Bishopric G, Bruner J, Butler J

出版信息

Arch Pathol Lab Med. 1985 Dec;109(12):1106-8.

PMID:3000318
Abstract

Cytomegalovirus (CMV) infection involving multiple organ systems is a common finding in the acquired immunodeficiency syndrome. Acute CMV neuritis was a complication in two patients with acquired immunodeficiency syndrome. The diagnosis was made in both patients at autopsy, where typical CMV inclusions in the lumbar dorsal roots were noted in one patient and the same inclusions were found in the retroperitoneal peripheral nerves in a second patient. Electron microscopy confirmed the presence of viral particles in affected nerve segments. Patient 1 was hospitalized for ascending motor paralysis that remained unexplained at the time of death. In patient 2 the finding of CMV neuritis was incidental. Although CMV infection has been cited as an event antecedent to acute inflammatory polyradiculopathy (Guillain-Barré syndrome), to our knowledge morphologic evidence of the presence of virus has not been documented in this disease previously.

摘要

巨细胞病毒(CMV)感染累及多个器官系统是获得性免疫缺陷综合征中的常见表现。急性CMV神经炎是两名获得性免疫缺陷综合征患者的并发症。两名患者均在尸检时确诊,其中一名患者在腰背部神经根发现典型的CMV包涵体,另一名患者在腹膜后周围神经发现相同的包涵体。电子显微镜证实受影响神经节段存在病毒颗粒。患者1因进行性运动性麻痹住院,直至死亡时病因仍不明。患者2的CMV神经炎是偶然发现的。虽然CMV感染被认为是急性炎性多发性神经根病(格林-巴利综合征)的前驱事件,但据我们所知,此前在该疾病中尚未有病毒存在的形态学证据记录。

相似文献

1
Guillain-Barré syndrome with cytomegalovirus infection of peripheral nerves.伴有外周神经巨细胞病毒感染的吉兰-巴雷综合征
Arch Pathol Lab Med. 1985 Dec;109(12):1106-8.
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Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findings.获得性免疫缺陷综合征中的巨细胞病毒感染。临床及尸检结果。
Arch Pathol Lab Med. 1988 May;112(5):540-4.
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Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome.获得性免疫缺陷综合征中的巨细胞病毒多发性神经根神经病
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[Cytomegalovirus encephalo-myelo-radiculitis in acquired immunodeficiency syndrome].[获得性免疫缺陷综合征中的巨细胞病毒性脑脊髓神经根炎]
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[Guillain-Barré syndrome with high titers of anti-GM2 and anti-GalNAc-GD1a antibody following cytomegalovirus hepatitis].[巨细胞病毒性肝炎后出现高滴度抗GM2和抗GalNAc-GD1a抗体的吉兰-巴雷综合征]
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Pathology of the motor-sensory axonal Guillain-Barré syndrome.运动感觉轴索性吉兰-巴雷综合征的病理学
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Disseminated talc granulomatosis. An unusual finding in a patient with acquired immunodeficiency syndrome and fatal cytomegalovirus infection.播散性滑石肉芽肿病。获得性免疫缺陷综合征合并致命性巨细胞病毒感染患者中的一种罕见发现。
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Ann Neurol. 1991 Feb;29(2):139-46. doi: 10.1002/ana.410290205.
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[Guillain-Barré syndrome and disturbance in multiple organs associated with cytomegalovirus infection].[吉兰-巴雷综合征与巨细胞病毒感染相关的多器官功能障碍]
No To Shinkei. 1990 Mar;42(3):245-51.

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Acute varicella-zoster virus ventriculitis and meningo-myelo-radiculitis in acquired immunodeficiency syndrome.获得性免疫缺陷综合征中的急性水痘带状疱疹病毒脑室炎和脑脊膜脊髓神经根炎
Acta Neuropathol. 1993;86(6):659-65. doi: 10.1007/BF00294307.
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Neurological complications in AIDS.艾滋病的神经并发症
J Neurol. 1987 Jun;234(5):269-79. doi: 10.1007/BF00314279.
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Am J Pathol. 1986 Sep;124(3):537-58.
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Cytomegalovirus (CMV) disease of the brain in AIDS and connatal infection: a comparative study by histology, immunocytochemistry and in situ DNA hybridization.艾滋病患者脑巨细胞病毒(CMV)病与先天性感染:一项组织学、免疫细胞化学及原位DNA杂交的对比研究
Acta Neuropathol. 1989;79(3):286-93. doi: 10.1007/BF00294663.
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Severe neuropathy in a patient with acquired immune deficiency syndrome (AIDS). Evidence for widespread cytomegalovirus infection of peripheral nerve and human immunodeficiency virus-like immunoreactivity of anterior horn cells.一名获得性免疫缺陷综合征(艾滋病)患者出现严重神经病变。有证据表明外周神经存在广泛的巨细胞病毒感染以及前角细胞有人类免疫缺陷病毒样免疫反应性。
Acta Neuropathol. 1989;79(3):255-61. doi: 10.1007/BF00294659.
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Acute myeloradiculitis due to cytomegalovirus as the initial manifestation of AIDS.巨细胞病毒所致急性脊髓神经根炎作为艾滋病的首发表现
J Neurol Neurosurg Psychiatry. 1989 Feb;52(2):270-4. doi: 10.1136/jnnp.52.2.270.
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Spinal cord lesions in the acquired immune deficiency syndrome (AIDS).
Neurosurg Rev. 1990;13(3):189-94. doi: 10.1007/BF00313017.
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