Liu Y, Liang Q F
Beijing Tongren Hospital Capital Medical University, Beijing Tongren Eye center, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Zhonghua Yan Ke Za Zhi. 2017 Mar 11;53(3):225-229. doi: 10.3760/cma.j.issn.0412-4081.2017.03.019.
Topical anti-inflammatory therapy has become the significant way of treating dry eye so far. However, as the long-term use of routine anti-inflammatory medications are restricted from their side effects, it is inevitable to explore safer and more effective alternatives. Essential fatty acids have proven to be anti-inflammatory systemically, which makes it possible to treat dry eye. Clinical trials have demonstrated that supplementation with either ω-3 or ω-6 essential fatty acids or both has multifactorial efficacies including improvement of subjective symptoms, alleviation of inflammation of ocular surface and eyelid margin, prolongation of tear break-up time and increase of tear flow secretion. Besides anti-inflammation effects, several basic researches have revealed that other mechanisms of essential fatty acids treating dry eye might lie in the corneal epithelial healing and tear secretion promotion. This review puts emphasis on the effectiveness, feasibility and mechanism of treating dry eye with essential fatty acids. .
局部抗炎治疗已成为目前治疗干眼症的重要方法。然而，由于常规抗炎药物的长期使用因其副作用而受到限制，探索更安全、更有效的替代方法是不可避免的。必需脂肪酸已被证明具有全身抗炎作用，这使得治疗干眼症成为可能。临床试验表明，补充ω-3或ω-6必需脂肪酸或两者同时补充具有多方面的疗效，包括改善主观症状、减轻眼表和睑缘炎症、延长泪膜破裂时间以及增加泪液分泌。除了抗炎作用外，一些基础研究还揭示，必需脂肪酸治疗干眼症的其他机制可能在于促进角膜上皮愈合和泪液分泌。本文综述重点关注必需脂肪酸治疗干眼症的有效性、可行性及机制。
