Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA.
Cornea. 2011 Mar;30(3):308-14. doi: 10.1097/ICO.0b013e3181f22e03.
To investigate the potential effect of dietary supplementation with omega-3 fatty acid on lipid composition of meibum, aqueous tear evaporation, and tear volume in patients with dry eye.
In a pilot, prospective, randomized, double-masked study, patients with dry eye received a daily dose of fish oil, containing 450 mg of eicosapentaenoic acid, 300 mg of docosahexaenoic acid, and 1000 mg of flaxseed oil (TheraTears Nutrition; Advanced Vision Research, Woburn, MA) for 90 days. There were 2 patient visits: baseline and final. At these visits, patients completed the ocular surface disease index to score subjective symptoms, and slit-lamp examinations, breakup time, corneal staining, Schirmer type I, fluorophotometry, evaporometry, and collection of meibomian gland secretion samples for lipid composition analysis were performed.
A total of 36 patients with dry eye completed the study. At the end of the study, 70% of the patients became asymptomatic, whereas for the placebo group, 37% [corrected] of the symptomatic patients became asymptomatic. Schirmer testing and fluorophotometry suggested that the omega-3 supplement increased tear secretion. The lipid composition of the samples collected from the omega-3 group was found to be very similar to that from the placebo group. No trends between groups were seen for other objective parameters.
Dietary supplementation with omega-3 fatty acids in dry eye showed no significant effect in meibum lipid composition or aqueous tear evaporation rate. On the other hand, the average tear production and tear volume was increased in the omega-3 group as indicated by both Schirmer testing and fluorophotometry.
研究ω-3 脂肪酸膳食补充剂对干眼症患者的睑脂组成、泪液蒸发和泪液量的潜在影响。
在一项初步的前瞻性随机双盲研究中，干眼症患者每天服用鱼油，含有 450 毫克二十碳五烯酸、300 毫克二十二碳六烯酸和 1000 毫克亚麻籽油（TheraTears Nutrition；Advanced Vision Research，Woburn，MA），持续 90 天。患者有 2 次就诊：基线和最后一次。在这些就诊中，患者完成了眼表疾病指数以评分主观症状，进行了裂隙灯检查、泪膜破裂时间、角膜染色、Schirmer Ⅰ型、荧光光度法、蒸发量和收集睑板腺分泌物进行脂质组成分析。
共有 36 例干眼症患者完成了研究。研究结束时，70%的患者无症状，而安慰剂组中，37%的有症状患者无症状。Schirmer 测试和荧光光度法表明，ω-3 补充剂增加了泪液分泌。从 ω-3 组收集的样本的脂质组成与安慰剂组非常相似。其他客观参数未显示组间趋势。
干眼症患者补充 ω-3 脂肪酸对睑脂组成或泪液蒸发率没有显著影响。另一方面，Schirmer 测试和荧光光度法均表明，ω-3 组的平均泪液产生和泪液量增加。
